Robert R. Wagner (1923–2001) was an American
virologist
Virology is the scientific study of biological viruses. It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host cells for reproduction, thei ...
who spent time on the faculty at
Yale University
Yale University is a Private university, private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the List of Colonial Colleges, third-oldest institution of higher education in the United Sta ...
,
Johns Hopkins University
Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hemisphere. It consiste ...
, and finally the
University of Virginia School of Medicine
The University of Virginia School of Medicine (UVA SoM) is the graduate medical school of the University of Virginia. The school's facilities are on the University of Virginia grounds adjacent to Academical Village in Charlottesville, Virginia. F ...
, from which he retired as
professor emeritus
''Emeritus'' (; female: ''emerita'') is an adjective used to designate a retired chair, professor, pastor, bishop, pope, director, president, prime minister, rabbi, emperor, or other person who has been "permitted to retain as an honorary title ...
in 1994. His research focused on the
vesicular stomatitis virus. Wagner died of
cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bl ...
in 2001.
Education
Wagner attended
Columbia College Columbia College may refer to one of several institutions of higher education in North America:
Canada
* Columbia College (Alberta), in Calgary
* Columbia College (British Columbia), a two-year liberal arts institution in Vancouver
* Columbia In ...
as an undergraduate and received his bachelor's degree in 1943, after which he began
medical school
A medical school is a tertiary educational institution, or part of such an institution, that teaches medicine, and awards a professional degree for physicians. Such medical degrees include the Bachelor of Medicine, Bachelor of Surgery (MBBS, MB ...
at
Yale Medical School
The Yale School of Medicine is the graduate medical school at Yale University, a private research university in New Haven, Connecticut. It was founded in 1810 as the Medical Institution of Yale College and formally opened in 1813.
The primary t ...
and received his
M.D.
Doctor of Medicine (abbreviated M.D., from the Latin ''Medicinae Doctor'') is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the M.D. denotes a professional degree. T ...
in 1946. Following his
internship
An internship is a period of work experience offered by an organization for a limited period of time. Once confined to medical graduates, internship is used practice for a wide range of placements in businesses, non-profit organizations and gover ...
, he joined the
U.S. Navy Medical Corps
The Medical Corps of the United States Navy is a staff corps consisting of military physicians in a variety of specialties. It is the senior corps among all staff corps, second in precedence only to line officers. The corps of commissioned offic ...
, where he was first exposed to virology research while assigned to the U.S. Navy Medical Research Institute in
Bethesda, Maryland
Bethesda () is an unincorporated, census-designated place in southern Montgomery County, Maryland. It is located just northwest of Washington, D.C. It takes its name from a local church, the Bethesda Meeting House (1820, rebuilt 1849), which ...
. He served from 1947 to 1949, and became a lieutenant in the navy reserves. After his time in the Navy, Wagner moved to England to work as a
postdoctoral fellow
A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pu ...
with
Christopher Andrewes
Sir Christopher Howard Andrewes (7 June 1896 – 31 December 1988) was a British virologist who discovered the human influenza A virus in 1933.
Education
Andrewes was educated at Highgate School and later studied medicine at St Bartholomew ...
.
Academic career
Wagner joined the faculty at
Yale University
Yale University is a Private university, private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the List of Colonial Colleges, third-oldest institution of higher education in the United Sta ...
in 1951 and then moved to
Johns Hopkins
Johns Hopkins (May 19, 1795 – December 24, 1873) was an American merchant, investor, and philanthropist. Born on a plantation, he left his home to start a career at the age of 17, and settled in Baltimore, Maryland where he remained for most ...
in 1957, where he became the director of the Infectious Disease Division and later the head of the Division of Virology. In 1967 Wagner moved to the
University of Virginia School of Medicine
The University of Virginia School of Medicine (UVA SoM) is the graduate medical school of the University of Virginia. The school's facilities are on the University of Virginia grounds adjacent to Academical Village in Charlottesville, Virginia. F ...
to serve as the chair of the Department of Microbiology. Under his leadership the department expanded dramatically, both in number of faculty and in breadth of research. Wagner also became the director of the newly created University of Virginia Cancer Center and was appointed the Marion McNulty and Marvin C. Weaver Professor of Oncology in 1984.
Following a brief stint as the virology section editor for the ''
Journal of Bacteriology
The ''Journal of Bacteriology'' is a biweekly peer-reviewed scientific journal established in 1916. It is published by the American Society for Microbiology and the editor in chief is George A. O'Toole (Dartmouth College). The journal is delayed op ...
'', run by the
American Society for Microbiology
The American Society for Microbiology (ASM), originally the Society of American Bacteriologists, is a professional organization for scientists who study viruses, bacteria, fungi, algae, and protozoa as well as other aspects of microbiology. It w ...
, Wagner served as the founding
editor-in-chief
An editor-in-chief (EIC), also known as lead editor or chief editor, is a publication's editorial leader who has final responsibility for its operations and policies.
The highest-ranking editor of a publication may also be titled editor, managing ...
of the ''
Journal of Virology
The ''Journal of Virology'' is a biweekly peer-reviewed scientific journal that covers research concerning all aspects of virology. It was established in 1967 and is published by the American Society for Microbiology
The American Society for Mic ...
'', working with fellow editors
Lloyd Kozloff
Lloyd M. Kozloff (1923–2012) was an American microbiologist and virologist. He served on the faculty of the University of Chicago, the University of Colorado Health Sciences Center, and University of California, San Francisco, where he beca ...
and
Norman Salzman. The journal launched in 1966, and Wagner continued in his role for 15 years, overseeing a large expansion in the size of the journal before stepping down in 1982 and being succeeded by
Edward M. Scolnick
Edward Scolnick is a core investigator at the Broad Institute, the former founding director of the Stanley Center for Psychiatric Research at Broad Institute, and former head of research and development at Merck Research Laboratories.
Education ...
.
With
Heinz Fraenkel-Conrat
Heinz Ludwig Fraenkel-Conrat (July 29, 1910 – April 10, 1999) was a biochemist, famous for his research on viruses.
Early life
Fraenkel-Conrat was born in Breslau/Germany.
He was the son of Lili Conrat and Professor Ludwig Fraenkel, direc ...
, Wagner collaborated in editing a vast 19-volume treatise called ''Comprehensive Virology''. The first volume was reviewed in 1975 as somewhat difficult to understand for those unfamiliar to the field, but likely valuable as a reference work.
In the early 1980s, Wagner was among the group of American virologists who helped organize and became the founding members of the
American Society for Virology
The American Society for Virology (ASV) is an American scientific society serving the community of researchers in virology. The organization was founded in 1981 and was the first scientific society in the world dedicated exclusively to virology.
F ...
.
Wagner retired and assumed
professor emeritus
''Emeritus'' (; female: ''emerita'') is an adjective used to designate a retired chair, professor, pastor, bishop, pope, director, president, prime minister, rabbi, emperor, or other person who has been "permitted to retain as an honorary title ...
status at the University of Virginia in 1994, though he continued to be an active member of the community. His department - now the Department of Microbiology, Immunology, and Cancer Biology - awards the Robert R. Wagner Prize to excellent graduate students.
Research
Wagner has been recognized as a major contributor to the development of molecular virology. During the early 1960s, while at Johns Hopkins, he became involved in research on
interferon
Interferons (IFNs, ) are a group of signaling proteins made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten t ...
s, which eventually entered clinical use. Much of his research focused on the
molecular biology
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and phys ...
of the
vesicular stomatitis virus. With student
Alice S. Huang
Alice S. Huang (; is an American biologist specialized in microbiology and virology. She served as President of AAAS during the 2010-2011 term.
Early years
Alice Huang's father, Quentin K. Y. Huang, was orphaned at age 12 in Anhui, China and was ...
, Wagner characterized what are now known as
defective interfering particle
Defective interfering particles (DIPs), also known as defective interfering viruses, are spontaneously generated virus mutants in which a critical portion of the particle's genome has been lost due to defective replication or non-homologous recomb ...
s.
References
{{DEFAULTSORT:Wagner, Robert R
1923 births
2001 deaths
American virologists
Columbia College (New York) alumni
University of Virginia School of Medicine faculty
Yale School of Medicine alumni
United States Navy Medical Corps officers
United States Navy reservists