Robert Cooley Elderfield (May 30, 1904 – December 10, 1979) was an American

chemist A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a graduated scientist trained in the study of chemistry, or an officially enrolled student in the field. Chemists study the composition of ...

. He was born in

Niagara Falls, New York Niagara Falls is a City (New York), city in Niagara County, New York, United States. As of the 2020 United States census, 2020 census, the city had a total population of 48,671. It is adjacent to the Niagara River, across from the city of Niagar ...

United States The United States of America (USA), also known as the United States (U.S.) or America, is a country primarily located in North America. It is a federal republic of 50 U.S. state, states and a federal capital district, Washington, D.C. The 48 ...

. Elderfield studied at the

Choate School Choate Rosemary Hall ( ) is a private, co-educational, college-preparatory boarding school in Wallingford, Connecticut, United States. Founded in 1890, it took its present name and began a co-educational system with the 1978 merger of ''The Ch ...

Wallingford, Connecticut Wallingford is a town in New Haven County, Connecticut, New Haven County, Connecticut, United States, centrally located between New Haven, Connecticut, New Haven and Hartford, Connecticut, Hartford, and Boston and New York City. The town is part ...

, later at the

University of Michigan The University of Michigan (U-M, U of M, or Michigan) is a public university, public research university in Ann Arbor, Michigan, United States. Founded in 1817, it is the oldest institution of higher education in the state. The University of Mi ...

receiving his Ph.D. from the

Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a Private university, private research university in Cambridge, Massachusetts, United States. Established in 1861, MIT has played a significant role in the development of many areas of moder ...

in 1930. He worked at the Rockefeller Institute of Medical Research from 1930 until 1936; in 1936, Elderfield changed to

Columbia University Columbia University in the City of New York, commonly referred to as Columbia University, is a Private university, private Ivy League research university in New York City. Established in 1754 as King's College on the grounds of Trinity Churc ...

. He was moved to

in 1952. Elderfield started his research with cardiac

glycoside In chemistry, a glycoside is a molecule in which a sugar is bound to another functional group via a glycosidic bond. Glycosides play numerous important roles in living organisms. Many plants store chemicals in the form of inactive glycosides. ...

s and cardiac

aglycone An aglycone (aglycon or genin) is the chemical compound remaining after the glycosyl group on a glycoside is replaced by a hydrogen atom. For example, the aglycone of a cardiac glycoside would be a steroid A steroid is an organic compoun ...

s shifting to the synthesis of primaquine and other

antimalarial Antimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young ...

s. At the end of his career, Elderfield did some research in new anticancer agents.

External links

Robert Elderfield's Biographical Memoir from the National Academy of Sciences
1904 births 1979 deaths 20th-century American chemists People from Niagara Falls, New York People from Wallingford, Connecticut University of Michigan alumni University of Michigan faculty Scientists from New York (state) Massachusetts Institute of Technology alumni {{US-chemist-stub