Ro67-4853 is a drug used in scientific research, which acts as a selective

positive allosteric modulator In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimuli. Some of them, like benzodiazepines or alcohol, function as psychoactive drugs. The site that ...

for the

metabotropic glutamate receptor The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic receptor, metabotropic process. They are members of the group C GPCR family, group C family of G-protein-coupled r ...

subtype mGluR₁. It was derived by modification of the simpler compound Ro01-6128, and has itself subsequently been used as a

lead compound A lead compound (, i.e. a "leading" compound, not to be confused with various compounds of the metallic element lead) in drug discovery is a chemical compound that has pharmacological or biological activity likely to be therapeutically useful, but ...

to develop a range of potent and selective mGluR₁ positive modulators.

References

Drugs developed by Hoffmann-La Roche Xanthenes Carbamates MGlu1 receptor agonists {{nervous-system-drug-stub

See also

References