Rnd2 is a small (~21 kDa) signaling
G protein
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their ...
(to be specific, a
GTPase
GTPases are a large family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a ...
), and is a member of the
Rnd subgroup of the
Rho family of GTPases.
It is encoded by the gene RND2.
Function
It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).
upplied by OMIMref name="entrez2">
This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking.
Clinical significance
The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene
BRCA1
Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the ''BRCA1'' () gene. Orthologs are common in other vertebrate species, whereas invertebrate genomes may encode a more distantly related gene. ''BRCA1'' is a ...
.
Interactions
Rnd2 has been shown to
interact with:
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ARHGAP5,
*
RACGAP1,
and
*
UBXD5.
References
Further reading
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