Rnd1 is a small (~21 kDa) signaling
G protein
G proteins, also known as guanine nucleotide-binding proteins, are a Protein family, family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell (biology), ...
(to be specific, a
GTPase
GTPases are a large family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a ...
), and is a member of the
Rnd subgroup of the
Rho family of GTPases
The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found ...
.
It is encoded by the gene RND1.
It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).
upplied by OMIMref name="entrez" />
Interactions
Rnd1 has been shown to
interact with
GRB7
Growth factor receptor-bound protein 7, also known as GRB7, is a protein that in humans is encoded by the ''GRB7'' gene.
Function
The product of this gene belongs to a small family of Signal transducing adaptor protein, adaptor proteins that a ...
,
PLXNB1
Plexin B1 is a protein of the plexin family that in humans is encoded by the ''PLXNB1'' gene.
Function
Within neural tissues, the plexin
A plexin is a protein which acts as a receptor for semaphorin family signaling proteins. It is classic ...
,
,
and
UBXD5.
References
Further reading
*
*
*
*
*
*
*
*
*
*
*
{{gene-12-stub