GTP-binding protein Rit2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''RIT2''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999).
upplied by OMIMref name="entrez"/>
RIT2 has been associated with Parkinson's disease in two large genetic studies. An gene expression study of postmortem brain has suggested RIT2 interacts with
interferon-γ signalling.
Interactions
RIT2 has been shown to
interact with
POU4F1.
References
Further reading
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