Rifaquizinone (RFQ, CBR-2092, TNP-2092) is an experimental

antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy ...

medication developed in China for the treatment of bacterial infections such as drug-resistant strains of ''

Staphylococcus aureus ''Staphylococcus aureus'' is a Gram-positive spherically shaped bacterium, a member of the Bacillota, and is a usual member of the microbiota of the body, frequently found in the upper respiratory tract and on the skin. It is often posi ...

''. It is an orally active

prodrug A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Instead of administering a drug directly, a corresponding prodrug can be ...

which is also a

codrug A codrug consists of two drug Moiety (chemistry), moieties, generally "active against the same disease", that are joined through one or more covalent bond, covalent chemical bonds to create a single new chemical entity; they can also be describe ...

, being cleaved inside the body to two active components, with half of the molecule being a

rifamycin The rifamycins are a group of antibiotics that are synthesized either naturally by the bacterium '' Amycolatopsis rifamycinica'' or artificially. They are a subclass of the larger family of ansamycins. Rifamycins are particularly effective aga ...

derivative, and the other half a

quinolone antibiotic Quinolone antibiotics constitute a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. They are used in human and veterinary medicine to treat bacterial infections, as wel ...

. It is in clinical trials for joint infections following surgery and acute bacterial skin and skin structure infections.

References

{{reflist Antibiotics Heterocyclic compounds with 4 rings Quinolizidines Pyrrolidines Piperidines Acetate esters Carboxylic acids Carboxamides Methoxy compounds Cyclopropyl compounds

See also

References