Richard C. Mulligan (born 1954) is an American scientist who is the Mallinckrodt Professor of Genetics at Harvard Medical School, the Director of the Harvard Gene Therapy Initiative and a visiting scientist at the Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology. He is also the head of SanaX at Sana Biotechnology.

Research and career

Mulligan started his career in gene therapy as an undergraduate in biology in

Alexander Rich Alexander Rich (15 November 1924 – 27 April 2015) was an American biologist and biophysicist. He was the William Thompson Sedgwick Professor of Biophysics at MIT (since 1958) and Harvard Medical School. Rich earned an A.B. ('' magna cum ...

's lab at MIT and was involved with early work controlling gene expression using

SV40 SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that is found to cause tumors in humans and animals, but most ofte ...

. He would earn his PhD in

biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...

Stanford University Leland Stanford Junior University, commonly referred to as Stanford University, is a Private university, private research university in Stanford, California, United States. It was founded in 1885 by railroad magnate Leland Stanford (the eighth ...

in 1980 working with

Paul Berg Paul Berg (June 30, 1926 – February 15, 2023) was an American biochemist and professor at Stanford University. He was the recipient of the Nobel Prize in Chemistry in 1980, along with Walter Gilbert and Frederick Sanger. The award recogniz ...

to develop viral vectors to express human and bacterial genes. He would then do his postdoctoral training at the Center for Cancer Research at MIT with

David Baltimore David Baltimore (born March 7, 1938) is an American biologist, university administrator, and 1975 Nobel Prize in Physiology or Medicine, Nobel laureate in Physiology or Medicine. He is a professor of biology at the California Institute of Tech ...

and

Phillip Sharp Phillip Allen Sharp (born June 6, 1944) is an American geneticist and molecular biologist who co-discovered RNA splicing. He shared the 1993 Nobel Prize in Physiology or Medicine with Richard J. Roberts for "the discovery that genes in eukary ...

. He would join the faculty of molecular biology and was a member of the

Whitehead Institute for Biomedical Research Whitehead may refer to: * Whitehead (comedo), a blocked sweat/sebaceous duct of the skin * Whitehead (bird), a small species of passerine bird, endemic to New Zealand * Whitehead building, heritage listed residence of the principal of the Univer ...

. During that time, he was a founding member of the Recombinant DNA Advisory Committee (RAC). In 1996, he joined Children's Hospital and Harvard to become the director of the Harvard Gene Therapy Initiative and an investigator of the

Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization headquartered in Chevy Chase, Maryland with additional facilities in Ashburn, Virginia. It was founded in 1953 by Howard Hughes, an American busin ...

. Mulligan is an active investor as the founding partner and senior managing director of Sarissa Capital Management from 2013 to 2016 along with Alex Denner when they worked together with

Carl Icahn Carl Celian Icahn (; born February 16, 1936) is an American businessman and investor. He is the founder and controlling shareholder of Icahn Enterprises, a public company and diversified conglomerate holding company based in Sunny Isles Beach, ...

. He would then join Icahn Capital as a portfolio manager in 2017. He serves as Director of

Enzon Pharmaceuticals Enzon Pharmaceuticals, Inc. is a pharmaceutical company. Its headquarters is in Piscataway, New Jersey. The company is a publicly traded company on NASDAQ under the symbol "ENZN". It's also doing marketing works in Asia areas such as China. In ...

, and Biogen Idec, Inc.

Awards

* 1981

MacArthur Fellows Program The MacArthur Fellows Program, also known as the MacArthur Fellowship and colloquially called the "Genius Grant", is a prize awarded annually by the MacArthur Foundation, John D. and Catherine T. MacArthur Foundation to typically between 20 and ...

* 1983

Searle Scholars Program The Searle Scholars Program is a career development award made annually to support 15 young faculty in biomedical research and chemistry at US universities and research centers. The goal of the award is to support to exceptional young scientists wh ...

*1993 ASBMB-Amgen Award

Works

* Lindemann, D., Patriquin, E., Feng, S. and Mulligan, R.C. 1997 "Versatile retrovirus vector systems for regulated gene expression in vitro and in vivo". ''Molecular Medicine'' 3:466-476. * Goodell, M.A., Rosenzweig, H-.K., Marks, D.G., DeMaria, M., Paradis, G., Grupp, S.A., Sieff, C.A., Mulligan, R.C. and Johnson, R.P. 1997. "Dye efflux studies suggest the existence of CD34-negative/low hematopoietic stem cells in multiple species". ''Nature Medicine'' 3:1337–1345. * Mach, N., Lantz, C.S., Galli, S.J., Reznikoff, G., Mihm, M., Small, C., Granstein, R., Beissert, S., Sadelain, M., Mulligan, R.C. and Dranoff, G. 1998. "Involvement of interleukin-3 in delayed-type hypersensitivity". ''Blood'' 92:778-783.

References

{{DEFAULTSORT:Mulligan, Richard C. 1954 births MacArthur Fellows Harvard Medical School faculty Living people Searle Scholars Program recipients Gene therapy Stanford University School of Medicine alumni Massachusetts Institute of Technology alumni Massachusetts Institute of Technology faculty Howard Hughes Medical Investigators