Melinta Therapeutics is an American

biopharmaceutical A biopharmaceutical, also known as a biological medical product, or biologic, is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources. Different from totally synthesized pharmaceuticals, t ...

firm that focuses on the design and development of novel

broad-spectrum antibiotic A broad-antimicrobial spectrum, spectrum antibiotic is an antibiotic that acts on the two major bacterial groups, Gram-positive and Gram-negative, or any antibiotic that acts against a wide range of disease-causing bacteria. These medications are ...

s for the treatment of antibiotic-resistant infections in hospital settings. The company is located in Parsippany, New Jersey. Melinta Therapeutics was a publicly traded company until 2019 when it went into

chapter 11 bankruptcy protection Chapter 11 of the United States Bankruptcy Code (Title 11 of the United States Code) permits reorganization under the bankruptcy laws of the United States. Such reorganization, known as Chapter 11 bankruptcy, is available to every business, wh ...

. It was transferred to affiliates of Deerfield Management and became privately held company after financial restructuring to eliminate debt.

History

The company was founded in 2000 as ''Rib-X Pharmaceuticals'', and became a publicly traded company. In mid-2011,

Sanofi Sanofi S.A. is a French Multinational corporation, multinational pharmaceutical and healthcare company headquartered in Paris, France. The corporation was established in 1973 and merged with Synthélabo in 1999 to form Sanofi-Synthélabo. In 200 ...

entered into a global research collaboration and licensing option with the company to develop and commercialize novel antibiotics. It was renamed Melinta Therapeutics in 2013. One of its products,

delafloxacin Delafloxacin sold under the brand name Baxdela among others, is a fluoroquinolone antibiotic used to treat acute bacterial skin and skin structure infections. It was developed by Melinta Therapeutics. Medical use Delafloxacin is indicated to tr ...

(BAXDELA®), a

fluoroquinolone Quinolone antibiotics constitute a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. They are used in human and veterinary medicine to treat bacterial infections, as well ...

antibiotic acquired from Wakunaga Pharmaceutical in 2006, was approved by the

FDA The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food ...

in 2017. By 2016, the company developed radezolid, a next-generation oxazolidinone for bacterial acne. Melinta also markets meropenem/vaborbactam (VABOMERE®) approved in 2017, and oritavancin (ORBACTIV®) approved in 2014. Melinta shredded off its discovery research team in late 2018 and moved its headquarters from New Haven to

Morristown, New Jersey Morristown () is a Town (New Jersey), town in and the county seat of Morris County, New Jersey, Morris County, in the U.S. state of New Jersey.

in early 2019. On December 27, 2019, Melinta Therapeutics filed for

Chapter 11 Chapter 11 of the United States Bankruptcy Code ( Title 11 of the United States Code) permits reorganization under the bankruptcy laws of the United States. Such reorganization, known as Chapter 11 bankruptcy, is available to every business, w ...

bankruptcy protection. In April 2020, it was transferred to affiliates of its creditor Deerfield Management. In 2023, Melinta achieved FDA approval for rezafungin (REZZAYO), an

echinocandin Echinocandins are a class of antifungal drugs that inhibit the synthesis of β-glucan in the fungal cell wall via noncompetitive inhibition of the enzyme 1,3-β glucan synthase. The class has been dubbed the "penicillin of antifungals," along w ...

antifungal indicated in patients 18 years of age or older who have limited or no alternative options for the treatment of

candidemia Fungemia is the presence of fungi or yeast in the blood. The most common type, also known as candidemia, candedemia, or systemic candidiasis, is caused by '' Candida'' species. Candidemia is also among the most common bloodstream infections ...

and

invasive candidiasis Invasive candidiasis is an infection ( candidiasis) that can be caused by various species of ''Candida'' yeast. Unlike ''Candida'' infections of the mouth and throat ( oral candidiasis) or vagina ( ''Candidal'' vulvovaginitis), invasive candidi ...

References

External links

* {{coord, 40.80164, -74.45860, type:landmark_globe:earth_region:US-NJ, display=title Pharmaceutical companies based in New Jersey Pharmaceutical companies of the United States Pharmaceutical companies established in 2000 Companies that filed for Chapter 11 bankruptcy in 2019 Morristown, New Jersey Companies based in Morris County, New Jersey 2000 establishments in Connecticut