RhoH (Ras homolog gene family, member H) is a small (~21 kDa) signaling
G protein
G proteins, also known as guanine nucleotide-binding proteins, are a Protein family, family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell (biology), ...
(more specifically a
GTPase
GTPases are a large family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a ...
), and is a member of the
Rac
RAC or Rac may refer to:
Organizations
* Radio Amateurs of Canada
* RATCH-Australia Corporation, electricity generator
* Refugee Action Collective (Victoria), Melbourne, Australia
* Religious Action Center of Reform Judaism, US
* Rent-A-Cent ...
subfamily of the family
Rho family of GTPases
The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular actin dynamics, and are found ...
.
It is encoded by the gene RHOH.
Gene
Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in
non-Hodgkin's lymphoma
Non-Hodgkin lymphoma (NHL), also known as non-Hodgkin's lymphoma, is a group of blood cancers that includes all types of lymphomas except Hodgkin lymphomas. Symptoms include enlarged lymph nodes, fever, night sweats, weight loss, and tire ...
s. Unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in
hemopoietic cells.
Interactions
RhoH has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with
ARHGDIA
Rho GDP-dissociation inhibitor 1 is a protein that in humans is encoded by the ''ARHGDIA'' gene.
Interactions
ARHGDIA has been shown to interact with:
* CDC42,
* RAC1,
* RHOA,
* Rac2
Rac2 (Ras-related C3 botulinum toxin substrate 2) is ...
.
References
Further reading
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