Renanolone (
INN), or 11-ketopregnanolone, also known as 5β-pregnan-3α-ol-11,20-dione, is a
synthetic neuroactive steroid which is described as a
general anesthetic
General anaesthetics (or anesthetics) are often defined as compounds that induce a loss of consciousness in humans or loss of righting reflex in animals. Clinical definitions are also extended to include an induced coma that causes lack of aware ...
but was never introduced for clinical use.
Its
isomer
In chemistry, isomers are molecules or polyatomic ions with identical molecular formula – that is, the same number of atoms of each element (chemistry), element – but distinct arrangements of atoms in space. ''Isomerism'' refers to the exi ...
s,
alfaxolone and
alfadolone, are also general anesthetics, and are known to act as
positive allosteric modulators of the
GABAA receptor, a property which is likely the case for renanolone as well.
Chemistry
See also
*
Alfadolone
*
Alfaxolone
*
Ganaxolone
*
Hydroxydione
Hydroxydione, as hydroxydione sodium succinate (, , ) (brand names Viadril, Predion, and Presuren), also known as 21-Hydroxy-5β-pregnane-3,20-dione, is a neuroactive steroid which was formerly used as a general anesthetic, but was discontinued d ...
*
Minaxolone
*
Pregnanolone
References
5β-Pregnanes
General anesthetics
Neurosteroids
Secondary alcohols
Diketones
GABAA receptor positive allosteric modulators
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