Relebactam is a chemical compound used in combination with antibiotics to improve their efficacy. As a
beta-lactamase inhibitor
Beta-lactamases, (β-lactamases) are enzymes () produced by bacteria that provide multi-resistance to beta-lactam antibiotics such as penicillins, cephalosporins, cephamycins, monobactams and carbapenems ( ertapenem), although carbapenems ...
, it blocks the ability of bacteria to break down a
beta-lactam antibiotic
β-lactam antibiotics (beta-lactam antibiotics) are antibiotics that contain a beta-lactam ring in their chemical
structure. This includes penicillin derivatives ( penams), cephalosporins and cephamycins ( cephems), monobactams, carbapenems a ...
. In the United States, relebactam is approved for use in the combination
imipenem/cilastatin/relebactam
Imipenem/cilastatin/relebactam, sold under the brand name Recarbrio, is a fixed-dose combination medication used as an antibiotic. In 2019, it was approved for use in the United States for the treatment of complicated urinary tract and complicat ...
(Recarbrio).
See also
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Avibactam
Avibactam is a non- β-lactam β-lactamase inhibitor developed by Actavis (now Teva) jointly with AstraZeneca. A new drug application for avibactam in combination with ceftazidime (branded as Avycaz) was approved by the FDA on February 25, 2 ...
References
Antibiotics
Beta-lactamase inhibitors
Nitrogen heterocycles
4-Piperidinyl compounds
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