Relaxin/insulin-like family peptide receptor 1, also known as RXFP1, is a human
G protein coupled receptor that is one of the
relaxin receptor
The relaxin receptors are a subclass of four closely related G protein-coupled receptors (GPCR) that bind relaxin peptide hormones.
Below is list of human relaxin receptors, their endogenous peptide hormones, and what downstream enzymes are ac ...
s.
It is a rhodopsin-like GPCR which is unusual in this class as it contains a large extracellular binding and signalling domain. Some reports suggest that RXFP1 forms homodimers, however the most recent evidence indicates that relaxin binds a non-homodimer of RXFP1.
See also
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Relaxin family peptide hormones
Relaxin family peptide hormones in humans are represented by seven members: three relaxin-like (RLN) and four insulin-like (INSL) peptides: RLN1, RLN2, RNL3, INSL3, INSL4, INSL5, INSL6. This subdivision into two classes (RLN and INSL) is ba ...
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Insulin/IGF/Relaxin family
The insulin/IGF/relaxin family is a group of evolutionary related proteins which possess a variety of hormonal activities. Family members in human include two subfamilies:
1) insulin and insulin-like growth factors
2) relaxin family peptides:
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Relaxin
Relaxin is a protein hormone of about 6000 Da first described in 1926 by Frederick Hisaw.
The relaxin family peptide hormones belong to the insulin superfamily and consists of seven peptides of high structural but low sequence similarity; rela ...
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Relaxin-3
References
Further reading
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External links
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G protein-coupled receptors
{{transmembranereceptor-stub