RuvB-like 1 (E. coli), also known as RUVBL1 and TIP49, is a human
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
. RUVBL1 can form a hexamer. The hexamer can form a dodecamer with
RUVBL2
RuvB-like 2 (E. coli), also known as RUVBL2, is a human gene coding for a protein belonging to the AAA+ family of proteins.
Function
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA hel ...
protein.
Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.
Interactions
RuvB-like 1 has been shown to
interact
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with:
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ACTL6A
Actin-like protein 6A is a protein that in humans is encoded by the ''ACTL6A'' gene.
Function
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both ...
,
*
Beta-catenin
Catenin beta-1, also known as beta-catenin (β-catenin), is a protein that in humans is encoded by the ''CTNNB1'' gene.
Beta-catenin is a dual function protein, involved in regulation and coordination of cell–cell adhesion and gene transcri ...
,
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EP400
E1A-binding protein p400 is a protein that in humans is encoded by the ''EP400'' gene.
Interactions
EP400 has been shown to interact with Transformation/transcription domain-associated protein, RuvB-like 1 and Myc
''Myc'' is a family of reg ...
,
[
* ]Myc
''Myc'' is a family of regulator genes and proto-oncogenes that code for transcription factors. The ''Myc'' family consists of three related human genes: ''c-myc'' ( MYC), ''l-myc'' ( MYCL), and ''n-myc'' ( MYCN). ''c-myc'' (also sometimes ref ...
,RUVBL2
RuvB-like 2 (E. coli), also known as RUVBL2, is a human gene coding for a protein belonging to the AAA+ family of proteins.
Function
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA hel ...
.
References
Further reading
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