RUB A535 (also known as Antiphlogistine) is a

rubefacient A rubefacient is a substance for topical application that produces redness of the skin, e.g. by causing dilation of the capillaries and an increase in blood circulation. It has sometimes been used to relieve acute or chronic pain, but there is limi ...

introduced in 1919 and manufactured by

Church & Dwight Church & Dwight Co., Inc. is an American consumer goods company focusing on personal care, household products, and specialty products. The company was founded in 1847 and is headquartered in Ewing, New Jersey. It is the parent company of well-kno ...

Montreal, Quebec Montreal is the List of towns in Quebec, largest city in the Provinces and territories of Canada, province of Quebec, the List of the largest municipalities in Canada by population, second-largest in Canada, and the List of North American cit ...

, Canada.

While little known outside of Canada, it is used there for the treatment of tough

muscle pain Myalgia or muscle pain is a painful sensation evolving from muscle tissue. It is a symptom of many diseases. The most common cause of acute myalgia is the overuse of a muscle or group of muscles; another likely cause is viral infection, espec ...

, arthritic pains, rheumatic pains,

bursitis Bursitis is the inflammation of one or more bursae (synovial sacs) of synovial fluid in the body. They are lined with a synovial membrane that secretes a lubricating synovial fluid. There are more than 150 bursae in the human body. The bursae (bu ...

lumbago Low back pain or lumbago is a common disorder involving the muscles, nerves, and bones of the back, in between the lower edge of the ribs and the lower fold of the buttocks. Pain can vary from a dull constant ache to a sudden sharp feeling. ...

, etc. Church and Dwight say on their website that nearly all the research, development and production of RUB A535 is carried out in Canada. Patients who are allergic to salicylates (ASA based drugs, such as

aspirin Aspirin () is the genericized trademark for acetylsalicylic acid (ASA), a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and inflammation, and as an antithrombotic. Specific inflammatory conditions that aspirin is ...

), or who are taking

anticoagulant An anticoagulant, commonly known as a blood thinner, is a chemical substance that prevents or reduces the coagulation of blood, prolonging the clotting time. Some occur naturally in blood-eating animals, such as leeches and mosquitoes, which ...

medications should avoid the use of the product. It is also recommended to not use it more than 3–4 times a day.

Ingredients

The active ingredients in RUB A535 are

camphor Camphor () is a waxy, colorless solid with a strong aroma. It is classified as a terpenoid and a cyclic ketone. It is found in the wood of the camphor laurel (''Cinnamomum camphora''), a large evergreen tree found in East Asia; and in the kapu ...

eucalyptus oil Eucalyptus oil is the generic name for distilled oil from the leaves of ''Eucalyptus'', a genus of the plant family Myrtaceae, mostly native to Australia but cultivated worldwide. Eucalyptus oil has a history of wide application, as a pharmace ...

menthol Menthol is an organic compound, specifically a Monoterpene, monoterpenoid, that occurs naturally in the oils of several plants in the Mentha, mint family, such as Mentha arvensis, corn mint and peppermint. It is a white or clear waxy crystallin ...

, and

methyl salicylate Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic compound with the formula C8H8O3. It is the methyl ester of salicylic acid. It is a colorless, viscous liquid with a sweet, fruity odor reminiscent of root beer (in which it ...

. Some formulations also contain

capsaicin Capsaicin (8-methyl-''N''-vanillyl-6-nonenamide) (, rarely ) is an active component of chili peppers, which are plants belonging to the genus ''Capsicum''. It is a potent Irritation, irritant for Mammal, mammals, including humans, and produces ...

and

triethanolamine Triethanolamine, or TEOA, is an organic compound with the chemical formula . It is a colourless, viscous liquid. It is both a tertiary amine and a triol. A triol is a molecule with three alcohol groups. Approximately 150,000 tonnes were produ ...

Varieties

Currently, RUB A535 has been released in a variety of products: * Originally, it was produced in a particular white cream, carrying a rather offensive medical odour. * Recently, the name was also given to a line of dual action back patches that change temperature (known as Hot-Cold patches). * An improved cream was also developed, claiming to be odorless, differing from their normal cream, which carries the same smell as most topical analgesics. * As of 2008, the "Ultra Heat" sport stick was released and shipped to many provinces, including Manitoba. It is sold as individual units containing 100g of spearmint-smelling cream in packaging resembling an orange-coloured, slightly taller than usual deodorant stick. Like some deodorant sticks, the cream is dispensed by first uncapping the unit, then turning a dial at the bottom of the unit, thus pushing the cream up and out through three slits at the top. * There is also a cold A535 named "Ice".

References in other disciplines

Historically, the then local distributor was involved in a notable case in the High Court of Australia, about State income tax, ''Denver Chemical Manufacturing Company v The Commissioner of Taxation (New South Wales)'
(1949) 79 CLR 296
It simply involved a difference of views about how to disclose income on a tax return, but is th
leading authority
in its area.

External links

Official Website

References

{{DEFAULTSORT:Rub A535 Analgesics Ointments Church & Dwight brands Goods manufactured in Canada

Ingredients

Varieties

See also

References in other disciplines

External links

References