Research Triangle Institute, operating as RTI International, is a
nonprofit organization
A nonprofit organization (NPO), also known as a nonbusiness entity, nonprofit institution, not-for-profit organization, or simply a nonprofit, is a non-governmental (private) legal entity organized and operated for a collective, public, or so ...
headquartered in the
Research Triangle Park
Research Triangle Park (RTP) is the largest research park in the United States; it occupies in North Carolina and hosts more than 300 companies and 65,000 workers. It is owned and managed by the Research Triangle Foundation, a private non-profi ...
in
North Carolina
North Carolina ( ) is a U.S. state, state in the Southeastern United States, Southeastern region of the United States. It is bordered by Virginia to the north, the Atlantic Ocean to the east, South Carolina to the south, Georgia (U.S. stat ...
, USA. RTI provides research and technical services. It was founded in 1958 with $500,000 in funding from local businesses and the three North Carolina universities that form the
Research Triangle
The Research Triangle, or simply The Triangle, are both common nicknames for a metropolitan area in the Piedmont (United States), Piedmont region of the U.S. state of North Carolina. Anchored by the cities of Raleigh, North Carolina, Raleigh an ...
. RTI research has covered topics like HIV/AIDS, healthcare, education curriculum and the environment.
History

In 1954, a building contractor, met with the North Carolina state treasurer and the president of
Wachovia
Wachovia was a diversified financial services company based in Charlotte, North Carolina. Before its acquisition by Wells Fargo and Company in 2008, Wachovia was the fourth-largest bank holding company in the United States, based on total asset ...
to discuss building a research park in North Carolina to attract new industries to the region.
They obtained support for the concept from the state governor,
Luther Hodges, and the three universities that form the research triangle:
University of North Carolina at Chapel Hill
The University of North Carolina at Chapel Hill (UNC, UNC–Chapel Hill, or simply Carolina) is a public university, public research university in Chapel Hill, North Carolina, United States. Chartered in 1789, the university first began enrolli ...
,
Duke University
Duke University is a Private university, private research university in Durham, North Carolina, United States. Founded by Methodists and Quakers in the present-day city of Trinity, North Carolina, Trinity in 1838, the school moved to Durham in 1 ...
and
North Carolina State University
North Carolina State University (NC State, North Carolina State, NC State University, or NCSU) is a public university, public Land-grant university, land-grant research university in Raleigh, North Carolina, United States. Founded in 1887 and p ...
.
The Research Triangle Institute (now RTI International) was formed by the park's founders as the research park's first tenant in 1958.
The following January, they announced that $1.425 million had been raised by the Research Triangle Foundation to fund the park and that $500,000 of it had been set aside for RTI International.
RTI started with three divisions: Isotope Development, Operational Sciences and Statistics Research.
Its first contract was a $4,500 statistical study of morbidity data from
Tennessee
Tennessee (, ), officially the State of Tennessee, is a landlocked U.S. state, state in the Southeastern United States, Southeastern region of the United States. It borders Kentucky to the north, Virginia to the northeast, North Carolina t ...
.
In RTI's first year of operation, it had 25 staff and $240,000 in research contracts.
Its early work was focused on statistics, but within a few years RTI expanded into radioisotopes, organic chemistry and polymers. In 1960, the institute had its first international research contract for an agricultural census in
Nigeria
Nigeria, officially the Federal Republic of Nigeria, is a country in West Africa. It is situated between the Sahel to the north and the Gulf of Guinea in the Atlantic Ocean to the south. It covers an area of . With Demographics of Nigeria, ...
.
RTI won contracts with the
Department of Education
An education ministry is a national or subnational government agency politically responsible for education. Various other names are commonly used to identify such agencies, such as Ministry of Education, Department of Education, and Ministry of Pub ...
,
Defense Department,
NASA
The National Aeronautics and Space Administration (NASA ) is an independent agencies of the United States government, independent agency of the federal government of the United States, US federal government responsible for the United States ...
and the
Atomic Energy Commission, growing to $3.4 million in contracts in 1964 and $85 million in 1988.
In 1971, RTI's staff of 430 was reorganized into four research groups: social and economic systems, statistical sciences, environmental sciences and engineering, and chemistry and life sciences. It also created a division for education called the Center for Education Research and Evaluation.
Four years later, RTI created the Office for International Programs to manage international projects.
RTI provided funding assistance to help found the
North Carolina School of Science and Mathematics
The North Carolina School of Science and Mathematics (NCSSM) is a two-year, public residential high school with two physical campuses located in Durham, North Carolina, and Morganton, North Carolina, that focuses on the intensive study of scie ...
in 1980. Two years later, it was part of a joint venture to create Microelectronics Center of North Carolina (MCNC), a non-profit whose computer network connected local K-12 schools.
RTI has had five presidents:
# George R. Herbert 1958 - 1988
# Thomas Wooten 1988 - 1998
# Victoria Franchetti Haynes 1998 - 2012
# Wayne Holden 2012 - 2022
# Tim J. Gabel 2022–Present
Organization
RTI International is a non-profit research organization. It was initially established by three local universities but it is managed by a separate board and management team.
RTI's structure consists of members of the corporation, the board of governors and corporate officers. The members of the corporation elect governors, who in turn create the organization's policies.
RTI also has a separate business called RTI Health Solutions, which supports biotech, diagnostic and medical device companies.
In 2012, the organization's largest service areas were in social, statistical and environmental sciences. More than half of RTI's staff have advanced degrees in one of 120 fields and work on approximately 1,200 projects at a time.
Projects

RTI International's research has spanned areas like cancer, pollution, drug abuse and education.
It manages the
National Laboratory Certification Program (NLCP).
RTI scientists
Monroe Wall and
Mansukh C. Wani synthesized the anti-cancer treatments
camptothecin
Camptothecin (CPT) is a topoisomerase inhibitor. It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the Bark (botany), bark of ''Camptotheca acuminata'' (� ...
in 1966, from the bark of the
Camptotheca tree, and
Taxol
Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. It is administered by ...
in 1971, from a Pacific yew tree. These two drugs account for $3 billion a year in sales by pharmaceutical companies.
In 1986, RTI was awarded a $4 million contract with the
National Cancer Institute
The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. ...
to conduct an eight-year clinical trial on the effects of an anti-smoking campaign. Two years later, RTI began a $4.4 million program to co-ordinate AIDS drug trials for the
National Institutes of Health
The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...
. This grew to $26 million by 1988.
RTI scientists helped to identify toxic chemicals in the
Love Canal
Love Canal was a neighborhood in Niagara Falls, New York, United States, infamous as the location of a landfill that became the site of an environmental disaster discovered in 1977. Decades of dumping toxic chemicals killed residents and harm ...
in the 1970s.
In 1978, RTI researched the possibility of improving solar cells for the
US Department of Energy
US or Us most often refers to:
* Us (pronoun), ''Us'' (pronoun), the objective case of the English first-person plural pronoun ''we''
* US, an abbreviation for the United States
US, U.S., Us, us, or u.s. may also refer to:
Arts and entertainme ...
and
coal gasification
In industrial chemistry, coal gasification is the process of producing syngas—a mixture consisting primarily of carbon monoxide (CO), hydrogen (), carbon dioxide (), methane (), and water vapour ()—from coal and water, air and/or oxygen.
H ...
for the
Environmental Protection Agency
Environmental Protection Agency may refer to the following government organizations:
* Environmental Protection Agency (Queensland), Australia
* Environmental Protection Agency (Ghana)
* Environmental Protection Agency (Ireland)
* Environmenta ...
in 1979. RTI trained Chinese government employees on using computer models to forecast pollution patterns before the 2008 Olympics in Beijing.
An RTI survey in 1973, commissioned by the
Bureau of Narcotics and Dangerous Drugs
The Bureau of Narcotics and Dangerous Drugs (BNDD) was a Federal law enforcement in the United States, federal law enforcement agency within the United States Department of Justice with the enumerated power of investigating the consumption, traff ...
, confirmed earlier research that found no connection between drug use and violent crime, despite perceptions of heroin users as more prone to violence. A 1975 study that RTI conducted for the National Institute of Alcohol Abuse and Alcoholism found that 28 percent of 13,000 teenagers polled were "problem drinkers", despite their age. A 1996 study by RTI and funded by
the Pentagon
The Pentagon is the headquarters building of the United States Department of Defense, in Arlington County, Virginia, across the Potomac River from Washington, D.C. The building was constructed on an accelerated schedule during World War II. As ...
found that drug abuse in the military had been reduced by 90 percent since 1980.
In 1975, RTI recommended that the
Bureau of the Mint halt expensive production of cents and replace half-dollars with a new dollar coin. In 2001, RTI scientists created a new thinfilm superlattice material that uses the
thermoelectric effect
The thermoelectric effect is the direct conversion of temperature differences to electric voltage and vice versa via a thermocouple. A thermoelectric device creates a voltage when there is a different temperature on each side. Conversely, when ...
to cool microprocessors. A 2009 study by RTI and the
Centers for Disease Control and Prevention
The Centers for Disease Control and Prevention (CDC) is the National public health institutes, national public health agency of the United States. It is a Federal agencies of the United States, United States federal agency under the United S ...
published in ''Health Affairs'' estimated that obesity in the US caused $147 billion in increased medical care costs annually. RTI also developed a reading skill measurement program, the Early Grade Reading Assessment (EGRA), for the
U.S. Agency for International Development (USAID) and the World Bank. The EGRA has been used in 70 languages and 50 countries.
In the 1980s, RTI created and distributed the
Architecture Design and Assessment System, a set of software programs that helped model intricate systems. The ADAS programs were produced until the mid-1990s.
RTI began working for USAID after the conflict between Iraq and the US began in 2003.
USAID work represented 35 percent of RTI's revenue by 2010. Under Iraq’s previous, highly centralized regime, citizens had almost no experience with local governance or active participation in the governing process. To inform and train Iraqis in local governance systems, RTI ultimately set up offices in Iraq’s 18 provinces. A staff of 200 people drawn from 33 countries, augmented by the hiring of 800 Iraqis, was deployed.
In 2004, Nextreme was spun off from RTI to develop a thermoelectric material for semiconductors commercially. In October 2018, RTI published a study showing that
heroin
Heroin, also known as diacetylmorphine and diamorphine among other names, is a morphinan opioid substance synthesized from the Opium, dried latex of the Papaver somniferum, opium poppy; it is mainly used as a recreational drug for its eupho ...
users who used
fentanyl
Fentanyl is a highly potent synthetic piperidine opioid primarily used as an analgesic (pain medication). It is 30 to 50 times more Potency (pharmacology), potent than heroin and 50 to 100 times more potent than morphine. Its primary Medici ...
testing strips were more likely to adopt safer drug habits.
RTI Press
RTI International funds RTI Press as a means of sharing multidisciplinary research and practical knowledge to reach a general audience. Since the late 2000's, RTI Press has published peer-reviewed,
open-access
Open access (OA) is a set of principles and a range of practices through which nominally copyrightable publications are delivered to readers free of access charges or other barriers. With open access strictly defined (according to the 2001 de ...
research briefs (
ISSN
An International Standard Serial Number (ISSN) is an eight-digit to uniquely identify a periodical publication (periodical), such as a magazine. The ISSN is especially helpful in distinguishing between serials with the same title. ISSNs a ...
2378-7929), policy briefs (
ISSN
An International Standard Serial Number (ISSN) is an eight-digit to uniquely identify a periodical publication (periodical), such as a magazine. The ISSN is especially helpful in distinguishing between serials with the same title. ISSNs a ...
2378-7937), research reports (
ISSN
An International Standard Serial Number (ISSN) is an eight-digit to uniquely identify a periodical publication (periodical), such as a magazine. The ISSN is especially helpful in distinguishing between serials with the same title. ISSNs a ...
2378-7902), methods report (
ISSN
An International Standard Serial Number (ISSN) is an eight-digit to uniquely identify a periodical publication (periodical), such as a magazine. The ISSN is especially helpful in distinguishing between serials with the same title. ISSNs a ...
2378-7813), occasional papers (
ISSN
An International Standard Serial Number (ISSN) is an eight-digit to uniquely identify a periodical publication (periodical), such as a magazine. The ISSN is especially helpful in distinguishing between serials with the same title. ISSNs a ...
2378-7996), conference proceedings (
ISSN
An International Standard Serial Number (ISSN) is an eight-digit to uniquely identify a periodical publication (periodical), such as a magazine. The ISSN is especially helpful in distinguishing between serials with the same title. ISSNs a ...
2690-0343), and monographs and books, including th
Essential Role of Language in Survey Researchedited by Tim J. Gabel and Mandy Sha.
References
External links
*
*
{{DEFAULTSORT:Rti International
Multidisciplinary research institutes
Non-profit organizations based in North Carolina
Research institutes in North Carolina
Research Triangle
1958 establishments in North Carolina
Life sciences industry
Organizations established in 1958
Love Canal