RTI-229, also known as (–)-3β-(4-iodophenyl)tropane-2β-pyrrolidine carboxamide and RTI-''4229''-229, is a potent and long-lasting
stimulant
Stimulants (also known as central nervous system stimulants, or psychostimulants, or colloquially as uppers) are a class of drugs that increase alertness. They are used for various purposes, such as enhancing attention, motivation, cognition, ...
drug which was developed in the 1990s as part of a large group of related analogues from the
phenyltropane family. With the combination of two potent
dopamine transporter
The dopamine transporter (DAT, also sodium-dependent dopamine transporter) is a membrane-spanning protein coded for in humans by the ''SLC6A3'' gene (also known as ''DAT1''), that pumps the neurotransmitter dopamine out of the synaptic cleft ba ...
(DAT) binding motifs attached to the
tropane
Tropane is a nitrogenous bicyclic organic compound. It is mainly known for the other alkaloids derived from it, which include atropine and cocaine, among others. Tropane alkaloids occur in plants of the families Erythroxylaceae (including coca) ...
ring, the p-
iodophenyl
In organic chemistry, the phenyl group, or phenyl ring, is a cyclic group of atoms with the formula , and is often represented by the symbol Ph (archaically φ) or Ø. The phenyl group is closely related to benzene and can be viewed as a benzene ...
group at the 3β-position and a
pyrrolidine carboxamide at 2β, RTI-229 has extremely high selectivity for the dopamine transporter (2600x and 4600x selective over
NET and
5-HTT respectively) and is one of the most DAT-selective compounds in the RTI series.
Uses
RTI-229 is mainly used in scientific research into the
dopamine
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic chemical of the catecholamine and phenethylamine families. It is an amine synthesized ...
reuptake transporter, with its extremely high DAT selectivity making it useful for distinguishing between DAT and NET binding sites in the brain to an even greater extent than related compounds such as
RTI-121.
Legal Status
RTI-229 is legal throughout the world as of 2010. Some jurisdictions such as the United States, Australia and New Zealand might however consider RTI-229 to be a
controlled substance analogue of
cocaine
Cocaine is a tropane alkaloid and central nervous system stimulant, derived primarily from the leaves of two South American coca plants, ''Erythroxylum coca'' and ''Erythroxylum novogranatense, E. novogranatense'', which are cultivated a ...
on the grounds of its related chemical structure.
See also
*
RTI-55
RTI(-''4229'')-55, also called RTI-55 or iometopane, is a phenyltropane-based stimulant, psychostimulant used in scientific research and in some medical applications. This drug was first cited in 1991. RTI-55 is a non-selective dopamine reuptake ...
*
RTI-160
*
List of Phenyltropanes
References
External links
Generic Adderall Uses & Side Effects
{{DEFAULTSORT:Rti-229
Carboxamides
1-Pyrrolidinyl compounds
4-Iodophenyl compounds
Tropanes
RTI compounds
Dopamine reuptake inhibitors
Stimulants
Sympathomimetic amines
Medical imaging
Neuroimaging