RTI-120
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(–)-2β-Carbophenoxy-3β-(p-
tolyl In organic chemistry, tolyl groups are functional groups related to toluene. They have the general formula . The change of the relative position of the methyl and the R substituent on the aromatic ring can generate three possible structural isom ...
)tropane (RTI-''4229''-120) is a
phenyltropane Phenyltropanes (PTs) were originally developed to reduce cocaine addiction and dependency. In general these compounds act as inhibitors of the plasmalemmal monoamine reuptake transporters. This research has spanned beyond the last couple decade ...
derivative which acts as a reasonably selective
dopamine reuptake inhibitor A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT). Reuptake inhibition is achieved when extracellular dop ...
, along with weaker inhibition of
noradrenaline Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone, neurotransmitter and neuromodulator. The name "noradrenaline" (from ...
and
serotonin Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, ...
reuptake. It has a reasonably fast rate of occupancy of dopamine transporters in the brain, though slower than that of
cocaine Cocaine is a tropane alkaloid and central nervous system stimulant, derived primarily from the leaves of two South American coca plants, ''Erythroxylum coca'' and ''Erythroxylum novogranatense, E. novogranatense'', which are cultivated a ...
itself. RTI-120 has a short duration of action, along with other p-methyl substituted phenyltropanes such as
RTI-150 RTI(-''4229'')-150, ((−)-2β-Carbocyclobutoxy-3β-(4-methylphenyl)tropane) is a phenyltropane derivative which acts as a potent dopamine reuptake inhibitor and stimulant drug. It is around 5x more potent than cocaine, but is more selective for ...
, RTI-171 and RTI-199, giving it a more similar pharmacological profile to cocaine compared to longer acting analogues like
RTI-121 (–)-2β-Carboisopropoxy-3β-(4-iodophenyl)tropane (RTI-''4229''-121, IPCIT) is a stimulant drug used in scientific research, which was developed in the early 1990s. RTI-121 is a phenyltropane based, highly selective dopamine reuptake inhibitor ...
and
RTI-177 RTI(-''4229'')-177 (2β-(3-phenylisoxazol-5-yl)-3β-(4-chlorophenyl)tropane, β-CPPIT) is a synthetic stimulant drug from the phenyltropane family, which acts as a DRI with micromolar affinity for the SERT. RTI-177 has an unusually long duratio ...
.


See also

* List of phenyltropanes * RTI-113


References

Tropanes RTI compounds Dopamine reuptake inhibitors 4-Tolyl compounds Phenyl compounds {{nervous-system-drug-stub