DNA-directed RNA polymerase II subunit RPB2 is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that in humans is encoded by the ''POLR2B''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA.
Interactions
POLR2B has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with
POLR2C
DNA-directed RNA polymerase II subunit RPB3 is an enzyme that in humans is encoded by the ''POLR2C'' gene.
Function
This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in ...
,
POLR2E
DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the ''POLR2E'' gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a se ...
,
[ ]POLR2H
DNA-directed RNA polymerases I, II, and III subunit RPABC3 is a protein that in humans is encoded by the ''POLR2H'' gene.
This gene encodes one of the essential subunits of RNA polymerase II that is shared by the other two eukaryotic DNA-directe ...
[ and ]POLR2L
DNA-directed RNA polymerases I, II, and III subunit RPABC5 is a protein that in humans is encoded by the ''POLR2L'' gene.
Function
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in ...
.[
]
References
Further reading
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