Serine/threonine protein kinase MST4, also known as mammalian STE20-like protein kinase 4 (MST-4), is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

that in humans is encoded by the ''MST4''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

Function

The product of this gene is a member of the GCK group III family of

kinase In biochemistry, a kinase () is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates. This process is known as phosphorylation, where the high-energy ATP molecule don ...

s, which are a subset of the Ste20-like kinases. The encoded protein contains an

amino-terminal The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide. Within a peptide, the amin ...

kinase domain, and a

carboxy-terminal The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, carboxy tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH). When t ...

regulatory domain that mediates

homodimerization In biochemistry, a protein dimer is a macromolecular complex or multimer formed by two protein monomers, or single proteins, which are usually non-covalently bound. Many macromolecules, such as proteins or nucleic acids, form dimers. The word ' ...

. The protein kinase localizes to the

Golgi apparatus The Golgi apparatus (), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic Cell (biology), cells. Part of the endomembrane system in the cytoplasm, it protein targeting, packages proteins ...

and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by

caspase-3 Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the ''CASP3'' gene. ''CASP3'' orthologs have been identified in numerous mammals for which complete genome data are available. Unique orthologs are also ...

''in vitro'', and may function in the

apoptotic Apoptosis (from ) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast. Biochemical events lead to characteristic cell changes ( morphology) and death. These ...

pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Interactions

RP6-213H19.1 has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...

with: *

CTTNBP2NL CTTNBP2 N-terminal-like protein is a protein that in humans is encoded by the ''CTTNBP2NL'' gene. It is a substrate for phosphorylation. Interactions CTTNBP2NL has been shown to interact with: * FAM40A, and * MOBKL3, * PDCD10, * PPP2CA, ...

, *

CTTNBP2 Cortactin-binding protein 2 is a protein that in humans is encoded by the ''CTTNBP2'' gene. Function This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulat ...

, *

FAM40A Protein FAM40A is a protein that is located on chromosome 1 in humans and is encoded by the ''FAM40A'' gene. Characteristics and secondary structure FAM40A has an isoelectric point of 5.92 and a molecular weight of 95,575 Dalton (unit), daltons. ...

, *

MOBKL3 Mps one binder kinase activator-like 3 is an enzyme that in humans is encoded by the ''MOBKL3'' gene. Function This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expr ...

, *

PDCD10 Programmed cell death protein 10 is a protein that in humans is encoded by the ''PDCD10'' gene. Function This gene encodes a protein, originally identified in a premyeloid cell line, with similarity to proteins that participate in apoptosis. ...

, *

STRN3 Striatin-3 is a protein that in humans is encoded by the ''STRN3'' gene. Interactions STRN3 has been shown to interact with: * CTTNBP2NL, * CTTNBP2, * FAM40A, * MOBKL3, * PDCD10, * PPP2CA, * PPP2R1A, * RP6-213H19.1, * STK24, and * ...

, and *

STRN Striatin is a protein that in humans is encoded by the ''STRN'' gene. Interactions STRN has been shown to interact with: * CTTNBP2NL, * CTTNBP2, * FAM40A, * MOBKL3, * PDCD10, * PPP2CA, * PPP2R1A, * RP6-213H19.1, * STK24, * S ...

Function

Interactions

References

Further reading