RNA-binding protein with serine-rich domain 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
that in humans is encoded by the ''RNPS1''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
This gene encodes a protein that is part of a post-splicing multiprotein complex, the
exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Two splice variants have been found for this gene; both variants encode the same protein.
Interactions
RNPS1 has been shown to
interact
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with
SART3 and
Pinin
Pinin is a protein that in humans is encoded by the ''PNN'' gene.
Interactions
Pinin has been shown to interact with Keratin 8, Keratin 18, Keratin 19, CTBP1
C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is en ...
.
References
Further reading
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External links
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