In
enzymology
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
, an RNA ligase (ATP) () is an
enzyme that
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction
:ATP + (ribonucleotide)n + (ribonucleotide)m
AMP + diphosphate + (ribonucleotide)n
+m
The 3
substrates of this enzyme are
ATP
ATP may refer to:
Companies and organizations
* Association of Tennis Professionals, men's professional tennis governing body
* American Technical Publishers, employee-owned publishing company
* ', a Danish pension
* Armenia Tree Project, non ...
,
(ribonucleotide)n, and
(ribonucleotide)m, whereas its 3
products are
AMP,
diphosphate, and
(ribonucleotide)n+m.
This enzyme belongs to the family of
ligases, specifically those forming phosphoric-ester bonds. The
systematic name of this enzyme class is poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming). Other names in common use include polyribonucleotide synthase (ATP), RNA ligase, polyribonucleotide ligase, and ribonucleic ligase.
Structural studies
As of late 2007, two
structures have been solved for this class of enzymes, with
PDB accession codes and .
References
*
EC 6.5.1
Enzymes of known structure
{{ligase-stub