Rho-related BTB domain-containing protein 1 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

that in humans is encoded by the ''RHOBTB1''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

. The protein encoded by this gene belongs to the Rho family, which is part of the

Ras superfamily The Ras superfamily, derived from "Rat sarcoma virus", is a protein superfamily of small GTPases. Members of the superfamily are divided into families and subfamilies based on their structure, sequence and function. The five main families are Ra ...

of small GTPases. It contains a GTPase domain, a proline-rich region, two tandem BTB (broad complex, tramtrack, and bric-à-brac) domains, and a conserved C-terminal region. This protein plays a role in small GTPase-mediated signal transduction and in the organization of the actin filament system. Alternative transcriptional splice variants of this gene have been characterized.

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