RAS-like, estrogen-regulated, growth inhibitor is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
in humans that is encoded by the RERG
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
[
]
RERG, a member of the
RAS superfamily
The Ras superfamily, derived from "Rat sarcoma virus", is a protein superfamily of small GTPases. Members of the superfamily are divided into families and subfamilies based on their structure, sequence and function. The five main families are Ras ...
of
GTPases
GTPases are a large family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a pro ...
, inhibits cell proliferation and tumor formation (Finlin et al., 2001
ubMed 11533059.
upplied by OMIM, Mar 2009
References
External links
PDBe-KBprovides an overview of all the structure information available in the PDB for Human Ras-related and estrogen-regulated growth inhibitor (RERG)
Further reading
Human proteins
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