Ras association domain-containing protein 5 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''RASSF5 or F5''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.
Interactions
RASSF5 has been shown to
interact with
RRAS
Ras-related protein R-Ras is a protein that in humans is encoded by the ''RRAS'' gene.
Interactions
RRAS has been shown to interact with:
* ARAF,
* Bcl-2,
* NCK1
Cytoplasmic protein NCK1 is a protein that in humans is encoded by the ...
,
,
[ MRAS][ and RASSF1.][
]
References
Further reading
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
{{PDB Gallery, geneid=83593