UV excision repair protein RAD23 homolog A is a
protein that in humans is encoded by the ''RAD23A''
gene.
Function
The protein encoded by this gene is one of two human homologs of ''Saccharomyces cerevisiae'' Rad23, a protein involved in
nucleotide excision repair
Nucleotide excision repair is a DNA repair mechanism. DNA damage occurs constantly because of chemicals (e.g. intercalating agents), radiation and other mutagens. Three excision repair pathways exist to repair single stranded DNA damage: Nucle ...
(NER). This protein was shown to interact with, and elevate the nucleotide excision activity of
3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in
base excision repair. This protein contains an
N-terminal
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide. Within a peptide, the ami ...
ubiquitin-like domain, which was reported to interact with
26S proteasome
Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases.
Proteasomes are part of a major mechanism by whi ...
, as well as with ubiquitin protein ligase
E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
Interactions
RAD23A has been shown to
interact with:
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Ataxin 3
Ataxin-3 is a protein that in humans is encoded by the ''ATXN3'' gene.
Clinical significance
Machado–Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by the ''ATXN3'' ...
,
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PSMD4,
and
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Sequestosome 1.
References
Further reading
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