Ras-related protein Rab-5A is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''RAB5A''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
RAB5A localizes to early
endosome
Endosomes are a collection of intracellular sorting organelles in eukaryotic cells. They are parts of the endocytic membrane transport pathway originating from the trans Golgi network. Molecules or ligands internalized from the plasma membra ...
s where it is involved in the recruitment of
RAB7A
Ras-related protein Rab-7a is a protein that in humans is encoded by the ''RAB7A'' gene.
Ras-related protein Rab-7a is involved in endocytosis, which is a process that brings substances into a cell. The process of endocytosis works by folding the ...
and the maturation of these compartments to early endosomes. It drives the maturation of endosomes by transporting
vacuolar (H+)-ATPases (V-ATPases) from trans-Golgi network to endocytic vesicles.
Interactions
RAB5A has been shown to
interact with:
*
CHML
CHML (900 AM) was a commercial radio station in Hamilton, Ontario, Canada, owned by Corus Entertainment. The station's long-time slogan was "Hometown Radio". It went off the air on August 14, 2024 at 1 p.m., shortly after Corus announced that ...
,
*
RABEP1
Rab GTPase-binding effector protein 1 is an enzyme that in humans is encoded by the ''RABEP1'' gene. It belongs to rabaptin protein family.
Interactions
RABEP1 has been shown to interact with:
* AP1G1,
* GGA1,
* GGA2,
* RAB4A
Ras-r ...
,
*
SDCBP,
and
*
ZFYVE20
References
Further reading
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{{PDB Gallery, geneid=5868