Rab11 family-interacting protein 1 (Rab11-FIP1) also known as Rab-coupling protein is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''RAB11FIP1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
Proteins of the large
Rab GTPase family (see for example
RAB1A) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP1 is one of many proteins that interact with and regulate Rab GTPases.
RAB11FIP1 has been identified as a novel protein involved in the regulation of
adiponectin trafficking and release from the adipocyte.
RAB11FIP1 expression, which is increased with increasing BMI in humans, inhibits the release of adiponectin from the adipocyte, potentially contributing to lower circulating levels of adiponectin observed in obese populations.
Interactions
RAB11FIP1 has been shown to
interact with
RAB11A and
RAB4A
Ras-related protein Rab-4A is a protein that in humans is encoded by the ''RAB4A'' gene.
Interactions
RAB4A has been shown to interact with:
* CD2AP,
* KIF3B,
* RAB11FIP1,
* RABEP1, and
* STX4
Syntaxin-4 is a protein that in humans ...
.
[
]
References
Further reading
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
{{Gene-8-stub