R81 may refer to:
*
R81 (South Africa)
The R81 is a provincial route in Limpopo, South Africa that connects Polokwane with the R524 at Nyavani via Giyani.
Route
The R81 starts at a junction with the R71 road in Polokwane (capital of the Limpopo Province), in the suburb of Fau ...
, a road
* , a destroyer of the Royal Navy
* , an aircraft carrier of the Royal Netherlands Navy
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