Pyrvinium (Viprynium) is an
anthelmintic
Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them without causing significant damage to the host. They may also ...
effective for
pinworms. Several forms of pyrvinium have been prepared with variable counter anions, such as
halide
In chemistry, a halide (rarely halogenide) is a binary chemical compound, of which one part is a halogen atom and the other part is an element or radical that is less electronegative (or more electropositive) than the halogen, to make a fl ...
s,
tosylate
In organic chemistry, a toluenesulfonyl group (tosyl group, abbreviated Ts or TosIn this article, "Ts", unless otherwise stated, means tosyl, not tennessine.) is a univalent functional group with the chemical formula . It consists of a tolyl ...
,
triflate
In organic chemistry, triflate (Preferred IUPAC name, systematic name: trifluoromethanesulfonate), is a functional group with the Chemical formula, formula and Chemical structure, structure . The triflate group is often represented by , as opp ...
and
pamoate
Pamoic acid, also called embonic acid, is a 2-Naphthoic acid derivative. Salts and esters of pamoic acid are known as pamoates or embonates. It can be prepared by the reaction of 3-hydroxy-2-naphthoic acid with formaldehyde.
In pharmacology ...
.
Pyrvinium was identified as a potent
Wnt inhibitor, acting through activation of
Casein kinase CK1α.
Pyrvinium salts can also inhibit the growth of cancer cells.
More specifically, the pamoate salt has been shown to have preferential toxicity for various cancer cell lines during glucose starvation.
Synthesis
One synthetic method is based on
Skraup synthesis and
Paal-Knorr synthesis.
More recently, an alternative convergent, synthetic strategy to pyrvinium triflate salts through
Friedländer synthesis was reported.
References
Anthelmintics
Pyrroles
Quinolines
Quaternary ammonium compounds
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