Pyroglutamyl-peptidase I (, also known as Pyrrolidonyl peptidase, is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
(a
cysteine peptidase
Cysteine (; symbol Cys or C) is a semiessential proteinogenic amino acid with the formula . The thiol side chain in cysteine enables the formation of disulfide bonds, and often participates in enzymatic reactions as a nucleophile. Cysteine is ...
) found in bacteria, plants and animals.
It can be used to distinguish certain Streptococcal organisms.
Other names are ''5-oxoprolyl-peptidase'', ''pyrase'', ''pyrrolidonyl arylamidase'', ''
pyroglutamate aminopeptidase
Pyroglutamate aminopeptidase is a type of enzyme that cleaves the peptide bond linking the N-terminal end of a polypeptide forming a cyclical lactam
A lactam is a Cyclic compound, cyclic amide, formally derived from an amino alkanoic acid throug ...
'', ''pyroglutamyl aminopeptidase'', ''L-pyroglutamyl peptide hydrolase'', ''pyrrolidone-carboxyl peptidase'', ''pyrrolidone-carboxylate peptidase'', ''
pyrrolidonyl peptidase
Pyroglutamyl-peptidase I (, also known as Pyrrolidonyl peptidase, is an enzyme (a cysteine peptidase) found in bacteria, plants and animals.
It can be used to distinguish certain Streptococcal organisms.
Other names are ''5-oxoprolyl-peptidase'', ...
'', ''L-pyrrolidonecarboxylate peptidase'', ''pyroglutamidase'', ''pyrrolidonecarboxylyl peptidase'') is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...
: Release of an
N-terminal
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide. Within a peptide, the amin ...
pyroglutamyl
Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid) is a ubiquitous but understudied natural amino acid derivative in which the free amino group of glutamic acid or glutamine condensation reaction, cyclizes to form a lactam. The name ...
group from a
polypeptide
Peptides are short chains of amino acids linked by peptide bonds. A polypeptide is a longer, continuous, unbranched peptide chain. Polypeptides that have a molecular mass of 10,000 Da or more are called proteins. Chains of fewer than twenty ...
, the second amino acid generally not being
Pro
Pro is an abbreviation meaning "professional".
Pro, PRO or variants thereof might also refer to:
People
* Miguel Pro (1891–1927), Mexican priest
* Pro Hart (1928–2006), Australian painter
* Mlungisi Mdluli (born 1980), South African ret ...
Human gene
PGPEP1
The ''PGPEP1'' gene in humans encodes the enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and th ...
See also
*
Pyrrolidonyl-beta-naphthylamide
*
P-Dimethylaminocinnamaldehyde
''p''-Dimethylaminocinnamaldehyde (DMACA) is an aromatic hydrocarbon. It is used in an acidic solution to detect indoles.
Use as a testing reagent
The DMACA is any of a number of acidified DMACA solutions:
* 0.117 g of DMACA, 39 mL of ethanol, 5 ...
*
Pyroglutamic acid
Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid) is a ubiquitous but understudied natural amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam. The names of pyroglutamic acid ...
*
2-Naphthylamine
2-Naphthylamine or 2-aminonaphthalene is one of two isomeric aminonaphthalenes, compounds with the formula C10H7NH2. It is a colorless solid, but samples take on a reddish color in air because of oxidation. It was formerly used to make azo dyes, b ...
References
External links
*
{{Portal bar, Biology, border=no
EC 3.4.19