Pyrithyldione (Presidon, Persedon) is a

psychoactive drug A psychoactive drug, psychopharmaceutical, mind-altering drug, consciousness-altering drug, psychoactive substance, or psychotropic substance is a chemical substance that alters psychological functioning by modulating central nervous system acti ...

invented in 1949. An improved method of manufacture was patented by Roche in 1959. It was used as a

hypnotic A hypnotic (from Ancient Greek, Greek ''Hypnos'', sleep), also known as a somnifacient or soporific, and commonly known as sleeping pills, are a class of psychoactive drugs whose primary function is to sleep induction, induce sleep and to trea ...

sedative A sedative or tranquilliser is a substance that induces sedation by reducing irritability or Psychomotor agitation, excitement. They are central nervous system (CNS) Depressant, depressants and interact with brain activity, causing its decelera ...

and presumed to be less toxic than

barbiturates Barbiturates are a class of depressant drugs that are chemically derived from barbituric acid. They are effective when used medically as anxiolytics, hypnotics, and anticonvulsants, but have physical and psychological addiction potential as ...

. Today, this substance is no longer used.

Agranulocytosis Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous lowered white blood cell count (leukopenia, most commonly of neutrophils) and thus causing neutropenia in the circulating blood. I ...

was sometimes reported as

adverse effect An adverse effect is an undesired harmful effect resulting from a medication or other intervention, such as surgery. An adverse effect may be termed a "side effect", when judged to be secondary to a main or therapeutic effect. The term compli ...

. Pyrithyldione is also a CYP2D6 inducer but is not as potent as glutethimide. s pyrithyldione (Benedorm) an enzyme inducer (author's transl)Pharmazie. 1982 Jan;37(1):69. In studies, it increased the O-demethylation of codeine by 20%.

References

Hypnotics Lactams Ketones GABAA receptor positive allosteric modulators Abandoned drugs {{sedative-stub

See also

References