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PyBOP (benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate) is a peptide
coupling A coupling is a device used to connect two shafts together at their ends for the purpose of transmitting power. The primary purpose of couplings is to join two pieces of rotating equipment while permitting some degree of misalignment or end mov ...
reagent used in solid phase
peptide synthesis In organic chemistry, peptide synthesis is the production of peptides, compounds where multiple amino acids are linked via amide bonds, also known as peptide bonds. Peptides are chemically synthesized by the condensation reaction of the carboxy ...
. It is used as a substitute for the
BOP reagent BOP (benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate) reagent is a reagent commonly used in the synthesis of peptides. Its use is discouraged because coupling using BOP liberates HMPA Hexamethylphosphoramide, often abbre ...
- avoiding the formation of the carcinogenic waste product
HMPA Hexamethylphosphoramide, often abbreviated HMPA, is a phosphoramide (an amide of phosphoric acid) with the formula This colorless liquid is a useful reagent in organic synthesis. Structure and reactivity HMPA is the oxide of the highly basic t ...
.


See also

*
BOP reagent BOP (benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate) reagent is a reagent commonly used in the synthesis of peptides. Its use is discouraged because coupling using BOP liberates HMPA Hexamethylphosphoramide, often abbre ...
* DEPBT, a related reagent that contains no phosphorus-nitrogen bonds *
HATU HATU (1- is(dimethylamino)methylene1H-1,2,3-triazolo ,5-byridinium 3-oxide hexafluorophosphate, Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium) is a reagent used in peptide coupling chemistry to generate an active ester from a carboxy ...
*
HBTU HBTU (2-(1''H''-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate, Hexafluorophosphate Benzotriazole Tetramethyl Uronium) is a coupling reagent used in solid phase peptide synthesis. It was introduced in 1978 and shows resistance ...


References

Hexafluorophosphates Peptide coupling reagents Benzotriazoles Pyrrolidines Biochemistry Biochemistry methods Reagents for biochemistry Quaternary phosphonium compounds {{Organic-compound-stub