A psychedelic experience (known colloquially as a trip) is a temporary
altered state of consciousness
An altered state of consciousness (ASC), also called an altered state of mind, altered mental status (AMS) or mind alteration, is any condition which is significantly different from a normal waking state. It describes induced changes in one's me ...
induced by the consumption of a
psychedelic substance (most commonly
LSD
Lysergic acid diethylamide, commonly known as LSD (from German ; often referred to as acid or lucy), is a semisynthetic, hallucinogenic compound derived from ergot, known for its powerful psychological effects and serotonergic activity. I ...
,
mescaline
Mescaline, also known as mescalin or mezcalin, and in chemical terms 3,4,5-trimethoxyphenethylamine, is a natural product, naturally occurring psychedelic drug, psychedelic alkaloid, protoalkaloid of the substituted phenethylamine class, found ...
,
psilocybin mushrooms
Psilocybin mushrooms, or psilocybin-containing mushrooms, commonly known as magic mushrooms or as shrooms, are a type of hallucinogenic mushroom and a polyphyletic informal group of fungi that contain the prodrug psilocybin, which turns into t ...
, or
DMT). For example, an acid trip is a psychedelic experience brought on by the use of LSD, while a mushroom trip is a psychedelic experience brought on by the use of psilocybin. Psychedelic experiences feature alterations in normal
perception
Perception () is the organization, identification, and interpretation of sensory information in order to represent and understand the presented information or environment. All perception involves signals that go through the nervous syste ...
such as visual distortions and a subjective
loss of self-identity, sometimes interpreted as
mystical experience
A religious experience (sometimes known as a spiritual experience, sacred experience, mystical experience) is a subjective experience which is interpreted within a religious framework. The concept originated in the 19th century, as a defense ag ...
s. Psychedelic experiences lack predictability, as they can range from being highly pleasurable (known as a good trip) to frightening (known as a
bad trip
A bad trip (also known as challenging experiences, acute intoxication from hallucinogens, psychedelic crisis, or emergence phenomenon) is an acute adverse psychological reaction to the effects of Psychoactive drug, psychoactive substances, namely ...
). The outcome of a psychedelic experience is heavily influenced by the person's mood, personality, expectations, and environment (also known as
set and setting
Set and setting, when referring to a psychedelic drug experience or the use of other psychoactive substances, means one's mindset (shortened to "set") and the physical and social environment (the "setting") in which the user has the experience ...
).
Researchers have interpreted psychedelic experiences in light of a range of scientific theories, including
model psychosis theory, filtration theory,
psychoanalytic theory
Psychoanalytic theory is the theory of the innate structure of the human soul and the dynamics of personality development relating to the practice of psychoanalysis, a method of research and for treating of Mental disorder, mental disorders (psych ...
, entropic brain theory,
integrated information theory, and
predictive processing. Psychedelic experiences are also induced and interpreted in religious and spiritual contexts.
Along with psilocybin's unique effect on the state of mind, psilocybin has been subject to the idea of being used for therapeutic treatments. This rapidly developing field of psilocybin-assisted therapy has produced promising results in studies targeting mental disorders like depression,
post-traumatic stress disorder (PTSD),
and obsessive-compulsive disorder (OCD).
Etymology
The term ''
psychedelic'' was coined by the psychiatrist
Humphrey Osmond during written correspondence with author
Aldous Huxley
Aldous Leonard Huxley ( ; 26 July 1894 – 22 November 1963) was an English writer and philosopher. His bibliography spans nearly 50 books, including non-fiction novel, non-fiction works, as well as essays, narratives, and poems.
Born into the ...
and presented to the New York Academy of Sciences by Osmond in 1957.
It is derived from the
Greek
Greek may refer to:
Anything of, from, or related to Greece, a country in Southern Europe:
*Greeks, an ethnic group
*Greek language, a branch of the Indo-European language family
**Proto-Greek language, the assumed last common ancestor of all kno ...
words and thus meaning "mind manifesting," the implication being that psychedelics can develop unused potentials of the human mind. The term ''trip'' was first coined by US Army scientists during the 1950s when they were experimenting with LSD.
Phenomenology
Despite several attempts that have been made, starting in the 19th and 20th centuries, to define common
phenomenological structures of the effects produced by classic psychedelics, a universally accepted taxonomy does not yet exist.
Visual alteration
A prominent element of psychedelic experiences is visual alteration.
Psychedelic visual alteration often includes spontaneous formation of complex flowing geometric visual patterning in the visual field.
When the eyes are open, the visual alteration is overlaid onto the objects and spaces in the physical environment; when the eyes are closed the visual alteration is seen in the "inner world" behind the eyelids.
These visual effects increase in complexity with higher dosages, and also when the eyes are closed.
The visual alteration does not normally constitute
hallucination
A hallucination is a perception in the absence of an external stimulus that has the compelling sense of reality. They are distinguishable from several related phenomena, such as dreaming ( REM sleep), which does not involve wakefulness; pse ...
s, because the person undergoing the experience can still distinguish between real and imagined visual phenomena, though in some cases, true hallucinations are present.
More rarely, psychedelic experiences can include complex hallucinations of objects, animals, people, or even whole landscapes.
Visual alterations also include other effects such as
afterimage
An afterimage, or after-image, is an image that continues to appear in the eyes after a period of exposure to the original image. An afterimage may be a normal phenomenon (physiological afterimage) or may be pathological (palinopsia). Illusory ...
s, shifting of color hues, and
pareidolia
Pareidolia (; ) is the tendency for perception to impose a meaningful interpretation on a nebulous stimulus (physiology), stimulus, usually visual, so that one detects an object, pattern, or meaning where there is none. Pareidolia is a specific bu ...
. The appearance of
colors
Color (or colour in Commonwealth English; see spelling differences) is the visual perception based on the electromagnetic spectrum. Though color is not an inherent property of matter, color perception is related to an object's light absorpt ...
and
light
Light, visible light, or visible radiation is electromagnetic radiation that can be visual perception, perceived by the human eye. Visible light spans the visible spectrum and is usually defined as having wavelengths in the range of 400– ...
are usually enhanced.
The visuals of psychedelics have been reproduced in video and image form using
artificial intelligence
Artificial intelligence (AI) is the capability of computer, computational systems to perform tasks typically associated with human intelligence, such as learning, reasoning, problem-solving, perception, and decision-making. It is a field of re ...
.
Mystical experiences
A number of studies by
Roland R. Griffiths and other researchers have concluded that high doses of
psilocybin
Psilocybin, also known as 4-phosphoryloxy-''N'',''N''-dimethyltryptamine (4-PO-DMT), is a natural product, naturally occurring tryptamine alkaloid and Investigational New Drug, investigational drug found in more than List of psilocybin mushroom ...
and other classic psychedelics trigger
mystical experience
A religious experience (sometimes known as a spiritual experience, sacred experience, mystical experience) is a subjective experience which is interpreted within a religious framework. The concept originated in the 19th century, as a defense ag ...
s in most research participants.
Mystical experiences have been measured by a number of
psychometric
Psychometrics is a field of study within psychology concerned with the theory and technique of measurement. Psychometrics generally covers specialized fields within psychology and education devoted to testing, measurement, assessment, and rela ...
scales, including the
Hood Mysticism Scale, the Spiritual Transcendence Scale, and the Mystical Experience Questionnaire.
The revised version of the Mystical Experience Questionnaire, for example, asks participants about four dimensions of their experience, namely the "mystical" quality, positive mood such as the experience of amazement, the loss of the usual sense of time and space, and the sense that the experience cannot be adequately conveyed through words.
The questions on the "mystical" quality in turn probe multiple aspects: the sense of "pure" being, the sense of unity with one's surroundings, the sense that what one experienced was real, and the sense of sacredness.
Some researchers have questioned the interpretation of the results from these studies and whether the framework and terminology of mysticism are appropriate in a scientific context, while other researchers have responded to those criticisms and argued that descriptions of mystical experiences are compatible with a scientific worldview.
A group of researchers concluded in a 2011 study that psilocybin "occasions personally and spiritually significant mystical experiences that predict long-term changes in behaviors, attitudes and values".
Some research has found similarities between psychedelic experiences and non-ordinary forms of consciousness experienced in
meditation
Meditation is a practice in which an individual uses a technique to train attention and awareness and detach from reflexive, "discursive thinking", achieving a mentally clear and emotionally calm and stable state, while not judging the meditat ...
and
near-death experience
A near-death experience (NDE) is a profound personal experience associated with death or impending death, which researchers describe as having similar characteristics. When positive, which the great majority are, such experiences may encompa ...
s.
The phenomenon of
ego dissolution
Ego death is a "complete loss of subjective self-identity". The term is used in various intertwined contexts, with related meanings. The 19th-century philosopher and psychologist William James uses the synonymous term "self-surrender", and Jungi ...
is often described as a key feature of the psychedelic experience.
Individuals who have psychedelic experiences often describe what they experienced as "more real" than ordinary experience. For example, the psychologist
Benny Shanon, after observing
ayahuasca
AyahuascaPronounced as in the UK and in the US. Also occasionally known in English as ''ayaguasca'' (Spanish-derived), ''aioasca'' (Brazilian Portuguese-derived), or as ''yagé'', pronounced or . Etymologically, all forms but ''yagé'' descen ...
trips, referred to "the assessment, very common with ayahuasca, that what is seen and thought during the course of intoxication defines the real, whereas the world that is ordinarily perceived is actually an illusion." Similarly, the psychiatrist
Stanislav Grof
Stanislav Grof (born July 1, 1931) is a Czech-born American psychiatrist. Grof is one of the principal developers of transpersonal psychology and research into the use of non-ordinary states of consciousness for purposes of psychological hea ...
described the LSD experience as "complex revelatory insights into the nature of existence… typically accompanied by a sense of certainty that this knowledge is ultimately more relevant and 'real' than the perceptions and beliefs we share in everyday life."
Bad trips
A "bad trip" is a highly unpleasant psychedelic experience.
A bad trip on psilocybin, for instance, often features intense anxiety, confusion, agitation, or even
psychotic
In psychopathology, psychosis is a condition in which a person is unable to distinguish, in their experience of life, between what is and is not real. Examples of psychotic symptoms are delusions, hallucinations, and disorganized or incoher ...
episodes.
Bad trips can be connected to the anxious ego-dissolution (AED) dimension of the
APZ questionnaire used in research on psychedelic experiences.
As of 2011, exact data on the frequency of bad trips are not available.
Some research suggests that the risk of a bad trip on psilocybin is higher when multiple drugs are used, when the user has a history of certain mental illnesses, and when the user is not supervised by a sober person.
In clinical research settings, precautions including the screening and preparation of participants, the training of the session monitors who will be present during the experience, and the selection of appropriate physical setting can minimize the likelihood of psychological distress.
Researchers have suggested that the presence of professional "
trip sitters" (i.e., session monitors) may significantly reduce the negative experiences associated with a bad trip.
In most cases in which anxiety arises during a supervised psychedelic experience, reassurance from the session monitor is adequate to resolve it; however, if distress becomes intense it can be treated pharmacologically, for example with the
benzodiazepine
Benzodiazepines (BZD, BDZ, BZs), colloquially known as "benzos", are a class of central nervous system (CNS) depressant, depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. They are prescribed t ...
diazepam
Diazepam, sold under the brand name Valium among others, is a medicine of the benzodiazepine family that acts as an anxiolytic. It is used to treat a range of conditions, including anxiety disorder, anxiety, seizures, alcohol withdrawal syndr ...
.
Research shows that preparing for the psychedelic experience, as well as the set and setting of the individual and environment they will be in, can help mitigate "bad trips
''.
Harvard Psychologist
Timothy Leary
Timothy Francis Leary (October 22, 1920 – May 31, 1996) was an American psychologist and author known for his strong advocacy of psychedelic drugs. Evaluations of Leary are polarized, ranging from "bold oracle" to "publicity hound". Accordin ...
has said that "set" and "setting" are important to the experience.
Set refers to the participants' internal state – their mental, emotional and physical state, as well as their intentions for the experience (whether they want to solve a complex problem, discover the underlying secrets of the universe, or heal from a past trauma) – the better these preliminary conditions, the better the experience usually goes.
Setting refers to the environment the experience will take place in. Leary and others have found that, due to the highly suggestible nature of the psychedelic experience, the environment the participant is in plays a critical role.
For example, a warmly decorated room with a comfortable couch, nice music and an overall welcoming atmosphere will have a much more positive effect than a cold stainless steel and concrete reinforced hospital room.
Taking these necessary precautions before a psychedelic experience, along with the presence of trained professionals, have been shown to significantly reduce an overall negative experience.
The psychiatrist
Stanislav Grof
Stanislav Grof (born July 1, 1931) is a Czech-born American psychiatrist. Grof is one of the principal developers of transpersonal psychology and research into the use of non-ordinary states of consciousness for purposes of psychological hea ...
wrote that unpleasant psychedelic experiences are not necessarily unhealthy or undesirable, arguing that they may have potential for psychological healing and lead to breakthrough and resolution of unresolved psychic issues. Drawing on
narrative theory, the authors of a 2021 study of 50 users of psychedelics found that many described bad trips as having been sources of insight or even turning points in life.
Scientific models
Link R. Swanson divides scientific frameworks for understanding psychedelic experiences into two waves. In the first wave, encompassing nineteenth- and twentieth-century frameworks, he includes model
psychosis
In psychopathology, psychosis is a condition in which a person is unable to distinguish, in their experience of life, between what is and is not real. Examples of psychotic symptoms are delusions, hallucinations, and disorganized or inco ...
theory (the
psychotomimetic paradigm), filtration theory, and
psychoanalytic theory
Psychoanalytic theory is the theory of the innate structure of the human soul and the dynamics of personality development relating to the practice of psychoanalysis, a method of research and for treating of Mental disorder, mental disorders (psych ...
.
In the second wave of theories, encompassing twenty-first-century frameworks, Swanson includes entropic brain theory,
integrated information theory, and
predictive processing.
Model psychosis theory
Researchers studying mescaline in the early twentieth century and LSD in the mid-twentieth century took interest in these drugs as producing a temporary "model psychosis" that could assist researchers and medical students in understanding the experiences of patients with
schizophrenia
Schizophrenia () is a mental disorder characterized variously by hallucinations (typically, Auditory hallucination#Schizophrenia, hearing voices), delusions, thought disorder, disorganized thinking and behavior, and Reduced affect display, f ...
and other psychotic disorders.
It was popular to compare between experiences of psychedelics and psychosis in the mid-20th century.
[Friesen P. Psychosis and psychedelics: Historical entanglements and contemporary contrasts. Transcultural Psychiatry. 2022;59(5):592-609. https://doi.org/10.1177/13634615221129116] The scales used in psychosis and psychedelic research, in the late-20th and 21st century, are more different.
Despite the many similarities that were observed between experiences of psychedelics and psychosis in the past, contemporary psychosis and psychedelic research highlight some features more than others (since they have different goals and assumptions), such as mysticism, connectedness, awe, peace, ego dissolution, hallucinations, suspiciousness, disorganization, hostility, grandiosity, and withdrawal.
Filtration theory
Aldous Huxley
Aldous Leonard Huxley ( ; 26 July 1894 – 22 November 1963) was an English writer and philosopher. His bibliography spans nearly 50 books, including non-fiction novel, non-fiction works, as well as essays, narratives, and poems.
Born into the ...
and
Humphrey Osmond applied the pre-existing ideas of filtration theory, which held that the brain filters what enters into consciousness, to explain psychedelic experiences (and it is from this paradigm that the term ''psychedelic'' is derived).
Huxley believed that the brain was filtering reality itself and that psychedelics granted conscious access to "
Mind at Large
The mind is that which thinks, feels, perceives, imagines, remembers, and wills. It covers the totality of mental phenomena, including both conscious processes, through which an individual is aware of external and internal circumstances, ...
," whereas Osmond believed that the brain was filtering aspects of the mind out of consciousness.
Swanson writes that Osmond's view seems "less radical, more compatible with
materialist
Materialism is a form of philosophical monism according to which matter is the fundamental substance in nature, and all things, including mental states and consciousness, are results of material interactions. According to philosophical materia ...
science, and less
epistemically and
ontologically committed" than Huxley's.
Supporting this theory, research has found that LSD disrupts
thalamic gating, leading to altered perceptions by allowing more information to flow through the brain's gatekeeping mechanisms.
Psychoanalytic theory
Psychoanalytic theory was the predominant interpretive framework in mid-twentieth-century
psychedelic-assisted psychotherapy.
For instance, Czech psychiatrist
Stanislav Grof
Stanislav Grof (born July 1, 1931) is a Czech-born American psychiatrist. Grof is one of the principal developers of transpersonal psychology and research into the use of non-ordinary states of consciousness for purposes of psychological hea ...
characterised psychedelic experiencing as "non-specific amplification of unconscious mental processes", and he analysed the phenomenology of the LSD experience (particularly the experience of what he termed psychospiritual death and rebirth) in terms of
Otto Rank
Otto Rank (; ; né Rosenfeld; 22 April 1884 – 31 October 1939) was an Austrian psychoanalyst, writer, and philosopher. Born in Vienna, he was one of Sigmund Freud's closest colleagues for 20 years, a prolific writer on psychoanalytic themes, ...
's theory of the unresolved memory of the primal birth trauma.
Entropic brain theory
Entropic brain theory is a theory of
consciousness
Consciousness, at its simplest, is awareness of a state or object, either internal to oneself or in one's external environment. However, its nature has led to millennia of analyses, explanations, and debate among philosophers, scientists, an ...
proposed in 2014 by neuroscientist
Robin Carhart-Harris and colleagues that was inspired by research on psychedelic drugs.
The theory suggests that the
entropy
Entropy is a scientific concept, most commonly associated with states of disorder, randomness, or uncertainty. The term and the concept are used in diverse fields, from classical thermodynamics, where it was first recognized, to the micros ...
of brain activity within certain limits indexes the richness of conscious states, particularly under the influence of psychedelics. This theory posits that elevated brain entropy correlates with heightened informational richness, suggesting that psychedelics increase brain criticality, making it more sensitive to internal and external perturbations. This enhanced state of brain activity is proposed to influence susceptibility to environmental factors ("set" and "setting") and potentially offer new insights for treating psychiatric and neurological disorders, including depression and disorders of consciousness.
Integrated information theory
Integrated information theory is a theory of consciousness proposing to explain all forms of consciousness, and has been applied specifically to psychedelic experiences by Andrew Gallimore.
Predictive processing
Sarit Pink-Hashkes and colleagues have applied the predictive processing paradigm in neuroscience to psychedelic experiences in order to formalize the idea of the entropic brain.
In religious and spiritual contexts
Alan Watts
Alan Wilson Watts (6 January 1915 – 16 November 1973) was a British and American writer, speaker, and self-styled "philosophical entertainer", known for interpreting and popularising Buddhist, Taoist, and Hinduism, Hindu philosophy for a Wes ...
likened psychedelic experiencing to the transformations of consciousness that are undertaken in
Taoism
Taoism or Daoism (, ) is a diverse philosophical and religious tradition indigenous to China, emphasizing harmony with the Tao ( zh, p=dào, w=tao4). With a range of meaning in Chinese philosophy, translations of Tao include 'way', 'road', ' ...
and
Zen
Zen (; from Chinese: ''Chán''; in Korean: ''Sŏn'', and Vietnamese: ''Thiền'') is a Mahayana Buddhist tradition that developed in China during the Tang dynasty by blending Indian Mahayana Buddhism, particularly Yogacara and Madhyamaka phil ...
, which he says is, "more like the correction of faulty perception or the curing of a disease… not an acquisitive process of learning more and more facts or greater and greater skills, but rather an unlearning of wrong habits and opinions." Watts further described the LSD experience as, "revelations of the secret workings of the brain, of the associative and patterning processes, the ordering systems which carry out all our sensing and thinking."
According to
Luis Luna, psychedelic experiences have a distinctly
gnosis
Gnosis is the common Greek noun for knowledge ( γνῶσις, ''gnōsis'', f.). The term was used among various Hellenistic religions and philosophies in the Greco-Roman world. It is best known for its implication within Gnosticism, where ...
-like quality; it is a learning experience that elevates consciousness and makes a profound contribution to personal development. For this reason, the plant sources of some psychedelic drugs such as ayahuasca and mescaline-containing cacti are sometimes referred to as "plant teachers" by those using those drugs.
Furthermore, psychedelic drugs have a history of religious use across the world that extends back for hundreds or perhaps thousands of years.
They are often called
entheogens
Entheogens are psychoactive substances used in spiritual and religious contexts to induce altered states of consciousness. Hallucinogens such as the psilocybin found in so-called "magic" mushrooms have been used in sacred contexts since ancien ...
because of the kinds of experiences they can induce,
however various entheogens happen to also be
hypnotics
A hypnotic (from Greek ''Hypnos'', sleep), also known as a somnifacient or soporific, and commonly known as sleeping pills, are a class of psychoactive drugs whose primary function is to induce sleep and to treat insomnia (sleeplessness).
Th ...
(
muscimol mushrooms),
deliriants
Deliriants are a subclass of hallucinogen. The term was coined in the early 1980s to distinguish these drugs from psychedelics such as LSD and dissociatives such as ketamine, due to their primary effect of causing delirium, as opposed to t ...
(''
jimsonweed'') or atypical/quasi-psychedelics like
cannabis
''Cannabis'' () is a genus of flowering plants in the family Cannabaceae that is widely accepted as being indigenous to and originating from the continent of Asia. However, the number of species is disputed, with as many as three species be ...
. Some small contemporary religious movements base their religious activities and beliefs around psychedelic experiences, such as
Santo Daime
Santo Daime () is a Universalism, universalistic/Syncretism, syncretic religion founded in the 1930s in the Brazilian Amazon rainforest, Amazonian States of Brazil, state of Acre State, Acre based on the teachings of Raimundo Irineu Serra, known ...
and the
Native American Church
The Native American Church (NAC), also known as Peyotism and Peyote Religion, is a Syncretism, syncretic Native American religion that teaches a combination of traditional Native Americans in the United States, Native American beliefs and eleme ...
.
Psilocybin-Assisted Therapy
Depression
Studies on psilocybin-assisted therapy have found participants experience reduced depressive symptoms afterwards, as well as reduced anxiety symptoms.
Studies have also found that reductions in symptoms continued long afterwards, suggesting psilocybin could potentially be effective as a long-term treatment.
Post-Traumatic Stress Disorder
Individuals who suffer from post-traumatic stress disorder (PTSD) may also benefit from psilocybin-assisted therapy.
Based on studies so far, MDMA-assisted therapy appears to be effective for reducing symptoms of PTSD, leading a group of researchers to argue that psilocybin-assisted therapy may also be effective in PTSD and call for a study on the topic.
Obsessive-Compulsive Disorder
In a study that reviewed a variety of drugs to determine if it had an impact on symptoms of OCD, psilocybin was also tested and determined effective in reducing symptoms.
This reduction in symptoms applied to all individuals who participated in the study, proving psilocybin to be very reliable along with efficiency in reducing OCD symptoms.
See also
*
APZ questionnaire
*
Cannabis and time perception
The effect of cannabis on time perception has been studied with inconclusive results. Studies show consistently throughout the literature that most cannabis users self-report the experience of a slowed perception of time. In the laboratory, resea ...
*
Default mode network
In neuroscience, the default mode network (DMN), also known as the default network, default state network, or anatomically the medial frontoparietal network (M-FPN), is a large-scale brain network primarily composed of the dorsal medial prefro ...
*
Eight-circuit model of consciousness
*
List of psychedelic literature
*
Numinous
Numinous () means "arousing spiritual or religious emotion; mysterious or awe-inspiring";Collins English Dictionary - 7th ed. - 2005 also "supernatural" or "appealing to the aesthetic sensibility." The term was given its present sense by the Ger ...
experience
*
Philosophy of psychedelics
*
Psychedelic microdosing
Psychedelic microdosing is a form of microdosing, drug microdosing in which sub-hallucinogenic doses of serotonergic psychedelics like LSD and psilocybin are taken for claimed cognitive and emotional benefits.
Uses, research, and effects
A vari ...
*
Psychonautics
*
Trip killer
*
Trip report
References
Further reading
*
*
*
*
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Psychedelia
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