Estradiol benzoate/hydroxyprogesterone caproate (EB/OHPC), sold under the brand name Primosiston among others, is a

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estrogen and

progestogen Progestogens, also sometimes written progestagens or gestagens, are a class of natural or synthetic steroid hormones that bind to and activate the progesterone receptors (PR). Progesterone is the major and most important progestogen in the body. ...

medication which is used to treat gynecological disorders and habitual abortion. It contains estradiol benzoate (EB), an estrogen, and hydroxyprogesterone caproate (OHPC), a

progestin A progestogen, also referred to as a progestagen, gestagen, or gestogen, is a type of medication which produces effects similar to those of the natural product, natural female sex hormone progesterone in the body. A progestin is a ''synthetic co ...

. The medication is given by

injection into muscle Intramuscular injection, often abbreviated IM, is the injection of a substance into a muscle. In medicine, it is one of several methods for parenteral administration of medications. Intramuscular injection may be preferred because muscles have l ...

Medical uses

EB/OHPC is used in the treatment of gynecological disorders such as menstrual disorders (e.g., amenorrhea, dysfunctional uterine bleeding) and

premenstrual syndrome Premenstrual syndrome (PMS) refers to emotional and physical symptoms that regularly occur in the one to two weeks before the start of each menstrual period. Symptoms resolve around the time menstrual bleeding begins. Different women experienc ...

, habitual abortion (threatened miscarriage), and for other indications.

Available forms

EB/OHPC is available in the form of ampoules of oil solutions containing 10 mg estradiol benzoate (EB) and 125 to 250 mg hydroxyprogesterone caproate (OHPC).

History

EB/OHPC was first introduced for medical use in 1955.

Society and culture

Brand names

EB/OHPC has been marketed under brand names including Dos Dias N, Lutes, Ostrolut, Primosiston (or Primosiston Inj. / Injection), Primosiston Fuerte, and Syngynon.

Availability

EB/OHPC has been mostly discontinued and hence is mostly no longer available. It remains marketed under the brand names Primosiston in Ecuador and Peru, Dos Dias N in Argentina, and Lutes in

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. It was previously marketed under the brand names Ostrolut in Austria; Primosiston (or Primosiston Inj. / Injection) ( Schering) in Argentina, Germany, Mexico,

Switzerland ). Swiss law does not designate a ''capital'' as such, but the federal parliament and government are installed in Bern, while other federal institutions, such as the federal courts, are in other cities (Bellinzona, Lausanne, Luzern, Neuchâtel ...

, and Venezuela; Primosiston Fuerte in Spain; and Syngynon in Germany, but these formulations have all been discontinued and hence are no longer available in these countries.

References

{{DEFAULTSORT:Estradiol benzoate hydroxyprogesterone caproate Combined estrogen–progestogen formulations