Potassium citrate (also known as tripotassium citrate) is a

potassium Potassium is a chemical element; it has Symbol (chemistry), symbol K (from Neo-Latin ) and atomic number19. It is a silvery white metal that is soft enough to easily cut with a knife. Potassium metal reacts rapidly with atmospheric oxygen to ...

salt In common usage, salt is a mineral composed primarily of sodium chloride (NaCl). When used in food, especially in granulated form, it is more formally called table salt. In the form of a natural crystalline mineral, salt is also known as r ...

citric acid Citric acid is an organic compound with the formula . It is a Transparency and translucency, colorless Weak acid, weak organic acid. It occurs naturally in Citrus, citrus fruits. In biochemistry, it is an intermediate in the citric acid cycle, ...

with the molecular formula K₃C₆H₅O₇. It is a white,

hygroscopic Hygroscopy is the phenomenon of attracting and holding water molecules via either absorption (chemistry), absorption or adsorption from the surrounding Natural environment, environment, which is usually at normal or room temperature. If water mol ...

crystalline powder. It is odorless with a saline taste. It contains 38.28% potassium by mass. In the monohydrate form, it is highly

and

deliquescent Hygroscopy is the phenomenon of attracting and holding water molecules via either absorption (chemistry), absorption or adsorption from the surrounding Natural environment, environment, which is usually at normal or room temperature. If water mol ...

. As a

food additive Food additives are substances added to food to preserve flavor or enhance taste, appearance, or other sensory qualities. Some additives, such as vinegar ( pickling), salt ( salting), smoke ( smoking) and sugar ( crystallization), have been used f ...

, potassium citrate is used to regulate acidity, and is known as

E number E numbers, short for Europe numbers, are codes for substances used as food additives, including those found naturally in many foods, such as vitamin C, for use within the European Union (EU) and European Free Trade Association (EFTA). Commonly ...

E332. Medicinally, it may be used to control

kidney stone Kidney stone disease (known as nephrolithiasis, renal calculus disease, or urolithiasis) is a crystallopathy and occurs when there are too many minerals in the urine and not enough liquid or hydration. This imbalance causes tiny pieces of cr ...

s derived from

uric acid Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the Chemical formula, formula C5H4N4O3. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a product of the meta ...

cystine Cystine is the oxidized derivative of the amino acid cysteine and has the formula (SCH2CH(NH2)CO2H)2. It is a white solid that is poorly soluble in water. As a residue in proteins, cystine serves two functions: a site of redox reactions and a mec ...

. In 2020, it was the 297th most commonly prescribed medication in the United States, with more than 1million prescriptions.

Synthesis

Potassium citrate can be synthesized by the neutralization of

which is achieved by the addition of

potassium bicarbonate Potassium bicarbonate ( IUPAC name: potassium hydrogencarbonate, also known as potassium acid carbonate) is the inorganic compound with the chemical formula KHCO3. It is a white solid. Production and reactivity It is manufactured by treating an ...

potassium carbonate Potassium carbonate is the inorganic compound with the formula . It is a white salt, which is soluble in water and forms a strongly alkaline solution. It is deliquescent, often appearing as a damp or wet solid. Potassium carbonate is mainly used ...

potassium hydroxide Potassium hydroxide is an inorganic compound with the formula K OH, and is commonly called caustic potash. Along with sodium hydroxide (NaOH), KOH is a prototypical strong base. It has many industrial and niche applications, most of which utili ...

to it. The solution can then be filtered and the solvent can be evaporated till granulation.

Uses

Potassium citrate is rapidly absorbed when given by mouth, and is excreted in the urine. Since it is an alkaline salt, it is effective in reducing the pain and frequency of

urination Urination is the release of urine from the bladder through the urethra in Placentalia, placental mammals, or through the cloaca in other vertebrates. It is the urinary system's form of excretion. It is also known medically as micturition, v ...

when these are caused by highly acidic urine. It is used for this purpose in dogs and cats, but is chiefly employed as a non-irritating

diuretic A diuretic () is any substance that promotes diuresis, the increased production of urine. This includes forced diuresis. A diuretic tablet is sometimes colloquially called a water tablet. There are several categories of diuretics. All diuretics ...

. Potassium citrate is an effective way to treat/manage

arrhythmia Arrhythmias, also known as cardiac arrhythmias, are irregularities in the cardiac cycle, heartbeat, including when it is too fast or too slow. Essentially, this is anything but normal sinus rhythm. A resting heart rate that is too fast – ab ...

, if the patient is hypokalemic. It is widely used to treat urinary calculi (

kidney stones Kidney stone disease (known as nephrolithiasis, renal calculus disease, or urolithiasis) is a crystallopathy and occurs when there are too many minerals in the urine and not enough liquid or hydration. This imbalance causes tiny pieces of cr ...

), and is often used by patients with cystinuria. A systematic review showed a significant reduction in the incidence of stone formation RR 0.26, 95% CI 0.10 to 0.68. It is also used as an alkalizing agent in the treatment of mild urinary tract infections, such as

cystitis A urinary tract infection (UTI) is an infection that affects a part of the urinary tract. Lower urinary tract infections may involve the bladder (cystitis) or urethra ( urethritis) while upper urinary tract infections affect the kidney (py ...

. It is also used in many

soft drinks A soft drink (see § Terminology for other names) is a class of non-alcoholic drink, usually (but not necessarily) carbonated, and typically including added sweetener. Flavors used to be natural, but now can also be artificial. The sweet ...

as a

buffering agent A buffer solution is a solution where the pH does not change significantly on dilution or if an acid or base is added at constant temperature. Its pH changes very little when a small amount of strong acid or base is added to it. Buffer solution ...

. Frequently used in an aqueous solution with other potassium salts, it is a wet chemical fire suppressant that is particularly useful against kitchen fires. Its alkaline pH encourages

saponification Saponification is a process of cleaving esters into carboxylate salts and Alcohol (chemistry), alcohols by the action of aqueous alkali. Typically aqueous sodium hydroxide solutions are used. It is an important type of alkaline hydrolysis. When the ...

to insulate the fuel from oxidizing air, and the

endothermic An endothermic process is a chemical or physical process that absorbs heat from its surroundings. In terms of thermodynamics, it is a thermodynamic process with an increase in the enthalpy (or internal energy ) of the system.Oxtoby, D. W; Gillis, ...

dehydration reaction In chemistry, a dehydration reaction is a chemical reaction that involves the loss of an H2O from the reacting molecule(s) or ion(s). This reaction results in the release of the H2O as water. When the reaction involves the coupling of two molecu ...

absorbs heat energy to reduce temperatures.Xiaofang Wangy ''et al'' 2019 ''IOP Conf. Ser.: Mater. Sci. Eng.'' 490 022047

Administration

Potassium citrate liquid is usually administered by mouth in a diluted aqueous solution, because of its somewhat caustic effect on the stomach lining, and the potential for other mild health hazards. Pill tablets also exist in normal, and extended-release formulations.

References

External links

*Tanner, G.A
"Potassium citrate improves renal function in rats with polycystic kidney disease"
''Journal of the American Society of Nephrology''. Retrieved December 17, 2016. {{Mineral supplements Food acidity regulators Citrates Potassium compounds E-number additives