The potassium channel RNA editing signal is an RNA element found in human

Kv1.1 Potassium voltage-gated channel subfamily A member 1 also known as Kv1.1 is a shaker related voltage-gated potassium channel that in humans is encoded by the ''KCNA1'' gene. Isaacs syndrome is a result of an autoimmune reaction against the Kv1 ...

and its homologues which directs the efficient modification of an

adenosine Adenosine (symbol A) is an organic compound that occurs widely in nature in the form of diverse derivatives. The molecule consists of an adenine attached to a ribose via a β-N9-glycosidic bond. Adenosine is one of the four nucleoside buildin ...

inosine Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N9-glycosidic bond. It was discovered in 1965 in analysis of RNA transferase. Inosine is commonly found in tRNAs and is ...

by an adenosine deaminase acting on RNA ( ADAR). The ADAR modification causes an isoleucine/

valine Valine (symbol Val or V) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α- amino group (which is in the protonated −NH3+ form under biological conditions), an α- carboxylic acid group (which is in the deprotona ...

recoding event which lies in the ion-conducting pore of the

potassium channel Potassium channels are the most widely distributed type of ion channel found in virtually all organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of c ...

. It is thought that this editing event targets the process of fast inactivation and allows a more rapid recovery from inactivation at negative potentials.

References

External links

* Cis-regulatory RNA elements {{molecular-cell-biology-stub