Pompilio is a surname. Notable people with the surname include:
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Afrânio Pompílio Gastos do Amaral
Afrânio is a Brazilian Municipalities of Brazil, municipality in the state of Pernambuco. It is the westernmost municipality of Pernambuco. It is located in the mesoregion of ''São Francisco River, São Francisco Pernambucano'' . Afrânio has a ...
(1894–1982), Brazilian herpetologist
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Arsénio Pompílio Pompeu de Carpo (1792–1869), Portuguese slave trader, freemason, poet and journalist
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Elvis Pompilio (born 1961), Belgian fashion designer
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Luca Pompilio (born 1992), Italian footballer
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Numa Pompilio Llona (1832–1907), Ecuadorian poet, journalist, educator, diplomat, and philosopher
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Pedro Pompilio (1949–2008), Argentine businessman and football chairman
{{surname, Pompilio