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A poison is any
chemical substance A chemical substance is a unique form of matter with constant chemical composition and characteristic properties. Chemical substances may take the form of a single element or chemical compounds. If two or more chemical substances can be com ...
that is harmful or
lethal Lethality (also called deadliness or perniciousness) is how capable something is of causing death. Most often it is used when referring to diseases, chemical weapons, biological weapons, or their toxic chemical components. The use of this term ...
to
living organisms An organism is any living thing that functions as an individual. Such a definition raises more problems than it solves, not least because the concept of an individual is also difficult. Many criteria, few of them widely accepted, have been pro ...
. The term is used in a wide range of scientific fields and industries, where it is often specifically defined. It may also be applied
colloquial Colloquialism (also called ''colloquial language'', ''colloquial speech'', ''everyday language'', or ''general parlance'') is the linguistic style used for casual and informal communication. It is the most common form of speech in conversation amo ...
ly or figuratively, with a broad sense. Whether something is considered a poison or not may depend on the amount, the circumstances, and what living things are present.
Poisoning Poisoning is the harmful effect which occurs when Toxicity, toxic substances are introduced into the body. The term "poisoning" is a derivative of poison, a term describing any chemical substance that may harm or kill a living organism upon ...
could be accidental or deliberate, and if the cause can be identified there may be ways to neutralise the effects or minimise the
symptoms Signs and symptoms are diagnostic indications of an illness, injury, or condition. Signs are objective and externally observable; symptoms are a person's reported subjective experiences. A sign for example may be a higher or lower temperature ...
. In
biology Biology is the scientific study of life and living organisms. It is a broad natural science that encompasses a wide range of fields and unifying principles that explain the structure, function, growth, History of life, origin, evolution, and ...
, a poison is a
chemical substance A chemical substance is a unique form of matter with constant chemical composition and characteristic properties. Chemical substances may take the form of a single element or chemical compounds. If two or more chemical substances can be com ...
causing
death Death is the end of life; the irreversible cessation of all biological functions that sustain a living organism. Death eventually and inevitably occurs in all organisms. The remains of a former organism normally begin to decompose sh ...
, injury or harm to
organism An organism is any life, living thing that functions as an individual. Such a definition raises more problems than it solves, not least because the concept of an individual is also difficult. Many criteria, few of them widely accepted, have be ...
s or their parts. In
medicine Medicine is the science and Praxis (process), practice of caring for patients, managing the Medical diagnosis, diagnosis, prognosis, Preventive medicine, prevention, therapy, treatment, Palliative care, palliation of their injury or disease, ...
, poisons are a kind of
toxin A toxin is a naturally occurring poison produced by metabolic activities of living cells or organisms. They occur especially as proteins, often conjugated. The term was first used by organic chemist Ludwig Brieger (1849–1919), derived ...
that are delivered passively, not actively. In industry the term may be negative, something to be removed to make a thing safe, or positive, an agent to limit unwanted
pests PESTS was an anonymous American activist group formed in 1986 to critique racism, tokenism, and exclusion in the art world. PESTS produced newsletters, posters, and other print material highlighting examples of discrimination in gallery represent ...
. In ecological terms, poisons introduced into the environment can later cause unwanted effects elsewhere, or in other parts of the
food chain A food chain is a linear network of links in a food web, often starting with an autotroph (such as grass or algae), also called a producer, and typically ending at an apex predator (such as grizzly bears or killer whales), detritivore (such as ...
.


Etymology

The word "poison" was first used in 1200 to mean "a deadly potion or substance"; the English term comes from the "...Old French poison, puison (12c., Modern French poison) "a drink", especially a medical drink, later "a (magic) potion, poisonous drink" (14c.), from Latin potionem (nominative potio) "a drinking, a drink", also "poisonous drink" (Cicero), from potare "to drink". The use of "poison" as an adjective ("poisonous") dates from the 1520s. Using the word "poison" with plant names dates from the 18th century. The term "
poison ivy Poison ivy is a type of allergenic plant in the genus '' Toxicodendron'' native to Asia and North America. Formerly considered a single species, '' Toxicodendron radicans'', poison ivies are now generally treated as a complex of three separate s ...
", for example, was first used in 1784 and the term "
poison oak Poison oak refers to two plant species in the genus '' Toxicodendron,'' both of which can cause skin irritation: *'' Toxicodendron diversilobum'' or Pacific poison oak, found in western North America *'' Toxicodendron pubescens'' or Atlantic po ...
" was first used in 1743. The term "
poison gas Many gases have toxic properties, which are often assessed using the LC50 (median lethal concentration) measure. In the United States, many of these gases have been assigned an NFPA 704 health rating of 4 (may be fatal) or 3 (may cause serious ...
" was first used in 1915.


Terminology

The term "poison" is often used
colloquial Colloquialism (also called ''colloquial language'', ''colloquial speech'', ''everyday language'', or ''general parlance'') is the linguistic style used for casual and informal communication. It is the most common form of speech in conversation amo ...
ly to describe any harmful substance—particularly
corrosive Corrosion is a natural process that converts a refined metal into a more chemically stable oxide. It is the gradual deterioration of materials (usually a metal) by chemical or electrochemical reaction with their environment. Corrosion engine ...
substances,
carcinogen A carcinogen () is any agent that promotes the development of cancer. Carcinogens can include synthetic chemicals, naturally occurring substances, physical agents such as ionizing and non-ionizing radiation, and biologic agents such as viruse ...
s,
mutagen In genetics, a mutagen is a physical or chemical agent that permanently changes genetic material, usually DNA, in an organism and thus increases the frequency of mutations above the natural background level. As many mutations can cause cancer in ...
s, teratogens and harmful
pollutant A pollutant or novel entity is a substance or energy introduced into the environment that has undesired effect, or adversely affects the usefulness of a resource. These can be both naturally forming (i.e. minerals or extracted compounds like oi ...
s, and to exaggerate the dangers of chemicals.
Paracelsus Paracelsus (; ; 1493 – 24 September 1541), born Theophrastus von Hohenheim (full name Philippus Aureolus Theophrastus Bombastus von Hohenheim), was a Swiss physician, alchemist, lay theologian, and philosopher of the German Renaissance. H ...
(1493–1541), the father of
toxicology Toxicology is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating ex ...
, once wrote: "Everything is poison, there is poison in everything. Only the dose makes a thing not a poison" (see
median lethal dose In toxicology, the median lethal dose, LD50 (abbreviation for " lethal dose, 50%"), LC50 (lethal concentration, 50%) or LCt50 is a toxic unit that measures the lethal dose of a given substance. The value of LD50 for a substance is the dose re ...
). The term "poison" is also used in a figurative sense: "His brother's presence poisoned the atmosphere at the party". The law defines "poison" more strictly. Substances not legally required to carry the label "poison" can also cause a medical condition of poisoning. Some poisons are also
toxins A toxin is a naturally occurring poison produced by metabolic activities of living cells or organisms. They occur especially as proteins, often conjugated. The term was first used by organic chemist Ludwig Brieger (1849–1919), derived ...
, which is any poison produced by an organism, such as the
bacteria Bacteria (; : bacterium) are ubiquitous, mostly free-living organisms often consisting of one Cell (biology), biological cell. They constitute a large domain (biology), domain of Prokaryote, prokaryotic microorganisms. Typically a few micr ...
l
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
s that cause
tetanus Tetanus (), also known as lockjaw, is a bacterial infection caused by ''Clostridium tetani'' and characterized by muscle spasms. In the most common type, the spasms begin in the jaw and then progress to the rest of the body. Each spasm usually l ...
and
botulism Botulism is a rare and potentially fatal illness caused by botulinum toxin, which is produced by the bacterium ''Clostridium botulinum''. The disease begins with weakness, blurred vision, Fatigue (medical), feeling tired, and trouble speaking. ...
. A distinction between the two terms is not always observed, even among scientists. The derivative forms "toxic" and "poisonous" are synonymous. Animal poisons delivered
subcutaneously The subcutaneous tissue (), also called the hypodermis, hypoderm (), subcutis, or superficial fascia, is the lowermost layer of the integumentary system in vertebrates. The types of cells found in the layer are fibroblasts, adipose cells, and m ...
(e.g., by
sting Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a regulator protein that in humans is encoded by the STING1 gene. STING plays an important role in innate immunity. STING induces typ ...
or
bite Biting is an action involving a set of teeth closing down on an object. It is a common zoological behavior, being found in toothed animals such as mammals, reptiles, amphibians, fishes, and arthropods. Biting is also an action humans participate ...
) are also called ''venom''. In normal usage, a poisonous organism is one that is harmful to consume, but a venomous organism uses venom to kill its prey or defend itself while still alive. A single organism can be both poisonous and venomous, but it is rare. All living things produce substances to protect them from getting eaten, so the term "poison" is usually only used for substances which are poisonous to humans, while substances that mainly are poisonous to a common pathogen to the organism and humans are considered
antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy ...
s. Bacteria are for example a common adversary for ''
Penicillium chrysogenum ''Penicillium chrysogenum'' (formerly known as ''Penicillium notatum'') is a species of fungus in the genus ''Penicillium''. It is common in temperate and subtropical regions and can be found on salted food products, but it is mostly found in in ...
'' mold and humans, and since the mold's poison only targets bacteria, humans use it for getting rid of it in their bodies. Human
antimicrobial peptide Antimicrobial peptides (AMPs), also called host defence peptides (HDPs) are part of the innate immune response found among all classes of life. Fundamental differences exist between prokaryotic and eukaryotic cells that may represent targets for ...
s which are toxic to viruses, fungi, bacteria, and cancerous cells are considered a part of the immune system. In
nuclear physics Nuclear physics is the field of physics that studies atomic nuclei and their constituents and interactions, in addition to the study of other forms of nuclear matter. Nuclear physics should not be confused with atomic physics, which studies th ...
, a
poison A poison is any chemical substance that is harmful or lethal to living organisms. The term is used in a wide range of scientific fields and industries, where it is often specifically defined. It may also be applied colloquially or figurati ...
is a substance that obstructs or inhibits a nuclear reaction.
Environmentally hazardous Environmental hazards are hazards that affect biomes or ecosystems. Well known examples include oil spills, water pollution, slash and burn deforestation, air pollution, ground fissures, and Carbon dioxide in Earth's atmosphere, build-up of atmosp ...
substances are not necessarily poisons, and vice versa. For example, food-industry wastewater—which may contain potato juice or milk—can be hazardous to the ecosystems of streams and rivers by consuming oxygen and causing
eutrophication Eutrophication is a general term describing a process in which nutrients accumulate in a body of water, resulting in an increased growth of organisms that may deplete the oxygen in the water; ie. the process of too many plants growing on the s ...
, but is nonhazardous to humans and not classified as a poison. Biologically speaking, any substance, if given in large enough amounts, is poisonous and can cause death. For instance, several kilograms worth of water would constitute a lethal dose. Many substances used as medications—such as
fentanyl Fentanyl is a highly potent synthetic piperidine opioid primarily used as an analgesic (pain medication). It is 30 to 50 times more Potency (pharmacology), potent than heroin and 50 to 100 times more potent than morphine. Its primary Medici ...
—have an only one order of magnitude greater than the
ED50 ED50 ("European Datum 1950", EPSG:4230) is a geodetic datum which was defined after World War II for the international connection of geodetic networks. Background Some of the important battles of World War II were fought on the borders of Ger ...
. An alternative classification distinguishes between lethal substances that provide a therapeutic value and those that do not.


Modern definitions

In broad metaphorical (colloquial) usage of the term, "poison" may refer to anything deemed harmful. In
biology Biology is the scientific study of life and living organisms. It is a broad natural science that encompasses a wide range of fields and unifying principles that explain the structure, function, growth, History of life, origin, evolution, and ...
, poisons are substances that can cause
death Death is the end of life; the irreversible cessation of all biological functions that sustain a living organism. Death eventually and inevitably occurs in all organisms. The remains of a former organism normally begin to decompose sh ...
, injury, or harm to
organs In a multicellular organism, an organ is a collection of tissues joined in a structural unit to serve a common function. In the hierarchy of life, an organ lies between tissue and an organ system. Tissues are formed from same type cells to a ...
, tissues,
cells Cell most often refers to: * Cell (biology), the functional basic unit of life * Cellphone, a phone connected to a cellular network * Clandestine cell, a penetration-resistant form of a secret or outlawed organization * Electrochemical cell, a d ...
, and
DNA Deoxyribonucleic acid (; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of al ...
usually by chemical reactions or other activity on the
molecular A molecule is a group of two or more atoms that are held together by attractive forces known as chemical bonds; depending on context, the term may or may not include ions that satisfy this criterion. In quantum physics, organic chemistry, ...
scale, when an organism is exposed to a sufficient quantity.
Medicinal Medicine is the science and Praxis (process), practice of caring for patients, managing the Medical diagnosis, diagnosis, prognosis, Preventive medicine, prevention, therapy, treatment, Palliative care, palliation of their injury or disease, ...
fields (particularly
veterinary medicine Veterinary medicine is the branch of medicine that deals with the prevention, management, medical diagnosis, diagnosis, and treatment of disease, disorder, and injury in non-human animals. The scope of veterinary medicine is wide, covering all a ...
) and
zoology Zoology ( , ) is the scientific study of animals. Its studies include the anatomy, structure, embryology, Biological classification, classification, Ethology, habits, and distribution of all animals, both living and extinction, extinct, and ...
often distinguish poisons from ''
toxins A toxin is a naturally occurring poison produced by metabolic activities of living cells or organisms. They occur especially as proteins, often conjugated. The term was first used by organic chemist Ludwig Brieger (1849–1919), derived ...
'' and ''
venoms Venom or zootoxin is a type of toxin produced by an animal that is actively delivered through a wound by means of a bite, sting, or similar action. The toxin is delivered through a specially evolved ''venom apparatus'', such as fangs or a sti ...
''. Both poisons and venoms are toxins, which are
toxicant A toxicant is any toxic substance, whether artificial or naturally occurring. By contrast, a toxin is a poison produced naturally by an organism (e.g. plant, animal, insect, bacterium). The different types of toxicants can be found in the air, so ...
s produced by organisms in nature. The difference between venom and poison is the delivery method of the toxin. Venoms are toxins that are actively delivered by being injected via a bite or sting through a ''venom apparatus'', such as
fangs A fang is a long, pointed tooth. In mammals, a fang is a modified maxillary tooth, used for biting and tearing flesh. In snakes, it is a specialized tooth that is associated with a venom gland (see snake venom). Spiders also have external Chelic ...
or a
stinger A stinger (or sting) is a sharp organ found in various animals (typically insects and other arthropods) capable of injecting venom, usually by piercing the epidermis of another animal. An insect sting is complicated by its introduction of ve ...
, in a process called
envenomation Envenomation is the process by which venom is injected by the bite or sting of a venomous animal. Many kinds of animals, including mammals (e.g., the northern short-tailed shrew, ''Blarina brevicauda''), reptiles (e.g., many snakes), spiders, i ...
, whereas poisons are toxins that are passively delivered by being swallowed, inhaled, or absorbed through the skin. ''Unantidoteable'' refers to toxins that cannot be neutralized by modern medical technology, regardless of their type.


Uses

Industry Industry may refer to: Economics * Industry (economics), a generally categorized branch of economic activity * Industry (manufacturing), a specific branch of economic activity, typically in factories with machinery * The wider industrial sector ...
,
agriculture Agriculture encompasses crop and livestock production, aquaculture, and forestry for food and non-food products. Agriculture was a key factor in the rise of sedentary human civilization, whereby farming of domesticated species created ...
, and other sectors employ many poisonous substances, usually for reasons other than their
toxicity Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacteria, bacterium, or plant, as well as the effect o ...
to humans. Examples include medicines (e.g. anthelmintics used on chickens),
solvent A solvent (from the Latin language, Latin ''wikt:solvo#Latin, solvō'', "loosen, untie, solve") is a substance that dissolves a solute, resulting in a Solution (chemistry), solution. A solvent is usually a liquid but can also be a solid, a gas ...
s (e.g. rubbing alcohol, turpentine),
cleaners A cleaner, cleanser or cleaning operative is a type of industrial or domestic worker who is tasked with cleaning a space. A janitor (Scotland, United States and Canada), also known as a custodian, Facility Operator, porter or caretaker, is a pe ...
(e.g. bleach, ammonia),
coatings A coating is a covering that is applied to the surface of an object, or substrate. The purpose of applying the coating may be decorative, functional, or both. Coatings may be applied as liquids, gases or solids e.g. powder coatings. Paints and ...
(e.g. arsenic wallpaper), and
feedstock A raw material, also known as a feedstock, unprocessed material, or primary commodity, is a basic material that is used to produce goods, finished goods, energy, or intermediate materials/Intermediate goods that are feedstock for future finishe ...
s. The toxicity itself sometimes has economic value, when it serves agricultural purposes of
weed control Weed control is a type of pest control, which attempts to stop or reduce growth of weeds, especially noxious weeds, with the aim of reducing their competition with desired flora and fauna including domesticated plants and livestock, and in natu ...
and
pest control Pest control is the regulation or management of a species defined as a pest (organism), pest; such as any animal, plant or fungus that impacts adversely on human activities or environment. The human response depends on the importance of the da ...
. Most poisonous industrial compounds have associated
material safety data sheet A safety data sheet (SDS), material safety data sheet (MSDS), or product safety data sheet (PSDS) is a document that lists information relating to occupational safety and health for the use of various substances and products. SDSs are a wide ...
s and are classified as
hazardous substance Dangerous goods are substances that are a risk to health, safety, property or the environment during transport. Certain dangerous goods that pose risks even when not being transported are known as hazardous materials ( syllabically abbreviate ...
s. Hazardous substances are subject to extensive regulation on production, procurement, and use in overlapping domains of
occupational safety and health Occupational safety and health (OSH) or occupational health and safety (OHS) is a multidisciplinary field concerned with the safety, health, and welfare of people at work (i.e., while performing duties required by one's occupation). OSH is re ...
,
public health Public health is "the science and art of preventing disease, prolonging life and promoting health through the organized efforts and informed choices of society, organizations, public and private, communities and individuals". Analyzing the de ...
,
drinking water quality standards Drinking water quality standards describes the quality parameters set for drinking water. Water may contain many harmful constituents, yet there are no universally recognized and accepted international standards for drinking water. Even where st ...
,
air pollution Air pollution is the presence of substances in the Atmosphere of Earth, air that are harmful to humans, other living beings or the environment. Pollutants can be Gas, gases like Ground-level ozone, ozone or nitrogen oxides or small particles li ...
, and
environmental protection Environmental protection, or environment protection, refers to the taking of measures to protecting the natural environment, prevent pollution and maintain ecological balance. Action may be taken by individuals, advocacy groups and governments. ...
. Due to the mechanics of
molecular diffusion Molecular diffusion is the motion of atoms, molecules, or other particles of a gas or liquid at temperatures above absolute zero. The rate of this movement is a function of temperature, viscosity of the fluid, size and density (or their product, ...
, many poisonous compounds rapidly diffuse into biological tissues, air, water, or
soil Soil, also commonly referred to as earth, is a mixture of organic matter, minerals, gases, water, and organisms that together support the life of plants and soil organisms. Some scientific definitions distinguish dirt from ''soil'' by re ...
on a molecular scale. By the principle of
entropy Entropy is a scientific concept, most commonly associated with states of disorder, randomness, or uncertainty. The term and the concept are used in diverse fields, from classical thermodynamics, where it was first recognized, to the micros ...
, chemical contamination is typically costly or infeasible to reverse, unless specific
chelating Chelation () is a type of bonding of ions and their molecules to metal ions. It involves the formation or presence of two or more separate coordinate bonds between a polydentate (multiple bonded) ligand and a single central metal atom. These l ...
agents or micro-filtration processes are available. Chelating agents are often broader in scope than the acute target, and therefore their ingestion necessitates careful
medical Medicine is the science and Praxis (process), practice of caring for patients, managing the Medical diagnosis, diagnosis, prognosis, Preventive medicine, prevention, therapy, treatment, Palliative care, palliation of their injury or disease, ...
or
veterinarian A veterinarian (vet) or veterinary surgeon is a medical professional who practices veterinary medicine. They manage a wide range of health conditions and injuries in non-human animals. Along with this, veterinarians also play a role in animal r ...
supervision.
Pesticide Pesticides are substances that are used to control pests. They include herbicides, insecticides, nematicides, fungicides, and many others (see table). The most common of these are herbicides, which account for approximately 50% of all p ...
s are one group of substances whose prime purpose is their toxicity to various insects and other animals deemed to be pests (e.g.,
rat Rats are various medium-sized, long-tailed rodents. Species of rats are found throughout the order Rodentia, but stereotypical rats are found in the genus ''Rattus''. Other rat genera include '' Neotoma'' (pack rats), '' Bandicota'' (bandicoo ...
s and
cockroach Cockroaches (or roaches) are insects belonging to the Order (biology), order Blattodea (Blattaria). About 30 cockroach species out of 4,600 are associated with human habitats. Some species are well-known Pest (organism), pests. Modern cockro ...
es). Natural pesticides have been used for this purpose for thousands of years (e.g. concentrated
table salt In common usage, salt is a mineral composed primarily of sodium chloride (NaCl). When used in food, especially in granulated form, it is more formally called table salt. In the form of a natural crystalline mineral, salt is also known as ro ...
is toxic to many
slug Slug, or land slug, is a common name for any apparently shell-less Terrestrial mollusc, terrestrial gastropod mollusc. The word ''slug'' is also often used as part of the common name of any gastropod mollusc that has no shell, a very reduced ...
s and
snails A snail is a shelled gastropod. The name is most often applied to land snails, terrestrial molluscs, terrestrial pulmonate gastropod molluscs. However, the common name ''snail'' is also used for most of the members of the molluscan class Gas ...
).
Bioaccumulation Bioaccumulation is the gradual accumulation of substances, such as pesticides or other chemicals, in an organism. Bioaccumulation occurs when an organism absorbs a substance faster than it can be lost or eliminated by catabolism and excretion. T ...
of chemically-prepared agricultural
insecticide Insecticides are pesticides used to kill insects. They include ovicides and larvicides used against insect eggs and larvae, respectively. The major use of insecticides is in agriculture, but they are also used in home and garden settings, i ...
s is a matter of concern for the many species, especially
bird Birds are a group of warm-blooded vertebrates constituting the class (biology), class Aves (), characterised by feathers, toothless beaked jaws, the Oviparity, laying of Eggshell, hard-shelled eggs, a high Metabolism, metabolic rate, a fou ...
s, which consume insects as a primary food source. Selective toxicity, controlled application, and controlled
biodegradation Biodegradation is the breakdown of organic matter by microorganisms, such as bacteria and fungi. It is generally assumed to be a natural process, which differentiates it from composting. Composting is a human-driven process in which biodegrada ...
are major challenges in
herbicide Herbicides (, ), also commonly known as weed killers, are substances used to control undesired plants, also known as weeds.EPA. February 201Pesticides Industry. Sales and Usage 2006 and 2007: Market Estimates. Summary in press releasMain page f ...
and pesticide development and in
chemical engineering Chemical engineering is an engineering field which deals with the study of the operation and design of chemical plants as well as methods of improving production. Chemical engineers develop economical commercial processes to convert raw materials ...
generally, as all lifeforms on earth share an underlying
biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...
; organisms exceptional in their environmental resilience are classified as
extremophile An extremophile () is an organism that is able to live (or in some cases thrive) in extreme environments, i.e., environments with conditions approaching or stretching the limits of what known life can adapt to, such as extreme temperature, press ...
s, these for the most part exhibiting radically different susceptibilities.


Ecological lifetime

A poison which enters the
food chain A food chain is a linear network of links in a food web, often starting with an autotroph (such as grass or algae), also called a producer, and typically ending at an apex predator (such as grizzly bears or killer whales), detritivore (such as ...
—whether of industrial, agricultural, or
natural Nature is an inherent character or constitution, particularly of the ecosphere or the universe as a whole. In this general sense nature refers to the laws, elements and phenomena of the physical world, including life. Although humans are part ...
origin—might not be immediately toxic to the first organism that ingests the toxin, but can become further concentrated in
predator Predation is a biological interaction in which one organism, the predator, kills and eats another organism, its prey. It is one of a family of common List of feeding behaviours, feeding behaviours that includes parasitism and micropredation ...
y organisms further up the food chain, particularly
carnivore A carnivore , or meat-eater (Latin, ''caro'', genitive ''carnis'', meaning meat or "flesh" and ''vorare'' meaning "to devour"), is an animal or plant Plants are the eukaryotes that form the Kingdom (biology), kingdom Plantae; they ar ...
s and
omnivore An omnivore () is an animal that regularly consumes significant quantities of both plant and animal matter. Obtaining energy and nutrients from plant and animal matter, omnivores digest carbohydrates, protein, fat, and fiber, and metabolize t ...
s, especially concerning fat soluble poisons which tend to become stored in biological tissue rather than excreted in
urine Urine is a liquid by-product of metabolism in humans and many other animals. In placental mammals, urine flows from the Kidney (vertebrates), kidneys through the ureters to the urinary bladder and exits the urethra through the penile meatus (mal ...
or other water-based
effluents Effluent is wastewater from sewers or industrial outfalls that flows directly into surface waters, either untreated or after being treated at a facility. The term has slightly different meanings in certain contexts, and may contain various pollut ...
. Apart from food, many poisons readily enter the body through the
skin Skin is the layer of usually soft, flexible outer tissue covering the body of a vertebrate animal, with three main functions: protection, regulation, and sensation. Other animal coverings, such as the arthropod exoskeleton, have different ...
and
lung The lungs are the primary Organ (biology), organs of the respiratory system in many animals, including humans. In mammals and most other tetrapods, two lungs are located near the Vertebral column, backbone on either side of the heart. Their ...
s.
Hydrofluoric acid Hydrofluoric acid is a solution of hydrogen fluoride (HF) in water. Solutions of HF are colorless, acidic and highly corrosive. A common concentration is 49% (48–52%) but there are also stronger solutions (e.g. 70%) and pure HF has a boiling p ...
is a notorious contact poison, in addition to its
corrosive Corrosion is a natural process that converts a refined metal into a more chemically stable oxide. It is the gradual deterioration of materials (usually a metal) by chemical or electrochemical reaction with their environment. Corrosion engine ...
damage. Naturally occurring
sour gas Sour gas is natural gas or any other gas containing significant amounts of hydrogen sulfide (H2S). Natural gas is usually considered sour if there are more than 5.7 milligrams of H2S per cubic meter of natural gas, which is equivalent to approxima ...
is a fast-acting atmospheric poison, which can be released by
volcanic A volcano is commonly defined as a vent or fissure in the crust of a planetary-mass object, such as Earth, that allows hot lava, volcanic ash, and gases to escape from a magma chamber below the surface. On Earth, volcanoes are most often fo ...
activity or
drilling rig A drilling rig is an integrated system that Drilling, drills wells, such as oil or water wells, or holes for piling and other construction purposes, into the earth's subsurface. Drilling rigs can be massive structures housing equipment used to ...
s. Plant-based contact irritants, such as that possessed by
poison ivy Poison ivy is a type of allergenic plant in the genus '' Toxicodendron'' native to Asia and North America. Formerly considered a single species, '' Toxicodendron radicans'', poison ivies are now generally treated as a complex of three separate s ...
, are often classed as
allergen An allergen is an otherwise harmless substance that triggers an allergic reaction in sensitive individuals by stimulating an immune response. In technical terms, an allergen is an antigen that is capable of stimulating a type-I hypersensitivi ...
s rather than poisons; the effect of an allergen being not a poison as such, but to turn the body's immune system, natural defenses against itself. Poison can also enter the body through faulty implant (medicine), medical implants, or by injection (medicine), injection (which is the basis of lethal injection in the context of capital punishment). In 2013, 3.3 million cases of unintentional human poisonings occurred. This resulted in 98,000 deaths worldwide, down from 120,000 deaths in 1990. In modern society, cases of suspicious death elicit the attention of the Coroner's office and forensic science, forensic investigators. Of increasing concern since the isolation of natural radium by Marie Curie, Marie and Pierre Curie in 1898—and the subsequent advent of
nuclear physics Nuclear physics is the field of physics that studies atomic nuclei and their constituents and interactions, in addition to the study of other forms of nuclear matter. Nuclear physics should not be confused with atomic physics, which studies th ...
and nuclear technologies—are radioactive contamination, radiological poisons. These are associated with ionizing radiation, a mode of toxicity quite distinct from chemically active poisons. In mammals, chemical poisons are often passed from mother to offspring through the placenta during gestation, or through breast milk during breastfeeding, nursing. In contrast, radiological damage can be passed from mother or father to offspring through genetic mutation, which—if not fatal in gestation, miscarriage or list of genetic disorders, childhood, or a direct cause of infertility—can then be passed along again to a subsequent generation. Atmospheric radon is a natural radiological poison of increasing impact since humans moved from hunter-gatherer lifestyles and cave dweller, cave dwelling to increasingly enclosed structures able to radium and radon in the environment, contain radon in dangerous concentrations. The 2006 poisoning of Alexander Litvinenko was a notable use of radiological assassination, presumably meant to evade the normal investigation of chemical poisons. Poisons widely dispersed into the environment are known as pollution. These are often of human impact on the environment, human origin, but pollution can also include unwanted biological processes such as toxic red tide, or acute changes to the natural chemical environment attributed to invasive species, which are toxic or detrimental to the prior ecology (especially if the prior ecology was associated with human economic value or an established industry such as shellfish harvesting). The scientific disciplines of ecology and environmental resource management study the environmental life cycle of toxic compounds and their complex, diffuse, and highly interrelated effects.


Poisoning

Poisoning can be either acute or chronic, and caused by a variety of natural or synthetic substances. Substances that destroy tissue but do not absorb, such as lye, are classified as
corrosive Corrosion is a natural process that converts a refined metal into a more chemically stable oxide. It is the gradual deterioration of materials (usually a metal) by chemical or electrochemical reaction with their environment. Corrosion engine ...
s rather than poisons.


Acute

Acute poisoning is exposure to a poison on one occasion or during a short period of time. Symptoms develop in close relation to the exposure. Absorption of a poison is necessary for systemic poisoning. Furthermore, many common household medications are not labeled with skull and crossbones, although they can cause severe illness or even death. Poisoning can be caused by excessive consumption of generally safe substances, as in the case of water intoxication. Agents that act on the nervous system can paralyze in seconds or less, and include both biologically derived neurotoxins and so-called nerve gases, which may be synthesized for chemical warfare, warfare or industry. Inhaled or ingested cyanide, used as a method of execution in gas chambers, or as a suicide method, almost instantly starves the body of energy by enzyme inhibitor, inhibiting the enzymes in mitochondria that make Adenosine triphosphate, ATP. Intravenous injection of an unnaturally high concentration of potassium chloride, such as in the execution of prisoners in parts of the United States, quickly stops the heart by eliminating the Membrane potential, cell potential necessary for muscle contraction. Most biocides, including pesticides, are created to act as acute poisons to target organisms, although acute or less observable chronic poisoning can also occur in non-target organisms (secondary poisoning), including the humans who apply the biocides and other beneficial organisms. For example, the herbicide 2,4-D imitates the action of a plant hormone, which makes its lethal toxicity specific to plants. Indeed, 2,4-D is not a poison, but classified as "harmful" (EU). Many substances regarded as poisons are toxic only indirectly, by toxication. An example is "wood alcohol" or methanol, which is not poisonous itself, but is chemically converted to toxic formaldehyde and formic acid in the liver. Many Medication, drug molecules are made toxic in the liver, and the genetic variability of certain liver enzymes makes the toxicity of many compounds differ between individuals. Exposure to radioactive substances can produce radiation poisoning, an unrelated phenomenon. Two common cases of acute natural poisoning are theobromine poisoning of dogs and cats, and mushroom poisoning in humans. Dogs and cats are not natural herbivores, but a chemical defense developed by ''Theobroma cacao'' can be incidentally fatal nevertheless. Many omnivores, including humans, readily consume edible fungi, and thus many fungi have evolved to become Amanita phalloides, decisively inedible, in this case as a direct defense.


Chronic

Chronic poisoning is long-term repeated or continuous exposure to a poison where symptoms do not occur immediately or after each exposure. The person gradually becomes ill, or becomes ill after a long latent period. Chronic poisoning most commonly occurs following exposure to poisons that bioaccumulate, or are biomagnification, biomagnified, such as mercury (element), mercury, gadolinium, and lead.


Management

* Initial management for all poisonings includes ensuring adequate Cardiopulmonary resuscitation, cardiopulmonary function and providing treatment for any symptoms such as seizures, shock (circulatory), shock, and pain. * Injected poisons (e.g., from the sting of animals) can be treated by binding the affected body part with a pressure bandage and placing the affected body part in hot water (with a temperature of 50 °C). The pressure bandage prevents the poison being pumped throughout the body, and the hot water breaks it down. This treatment, however, only works with poisons composed of protein-molecules. * In the majority of poisonings the mainstay of management is providing supportive care for the patient, i.e., treating the symptoms rather than the poison.


Decontamination

* Treatment of a recently ingested poison may involve gastric decontamination to decrease absorption. Gastric decontamination can involve activated charcoal, gastric lavage, whole bowel irrigation, or nasogastric aspiration. Routine use of emetics (syrup of Ipecac), cathartics or laxatives are no longer recommended. ** Activated charcoal is the treatment of choice to prevent poison absorption. It is usually administered when the patient is in the emergency room or by a trained emergency healthcare provider such as a Paramedic or EMT. However, charcoal is ineffective against metals such as sodium, potassium, and lithium, and Alcohol (chemistry), alcohols and glycols; it is also not recommended for ingestion of corrosive chemicals such as acids and alkalis. ** Cathartics were postulated to decrease absorption by increasing the expulsion of the poison from the gastrointestinal tract. There are two types of cathartics used in poisoned patients; saline cathartics (sodium sulfate, magnesium citrate, magnesium sulfate) and saccharide cathartics (sorbitol). They do not appear to improve patient outcome and are no longer recommended. ** Emesis (i.e. induced by ipecac) is no longer recommended in poisoning situations, because vomiting is ineffective at removing poisons. ** Gastric lavage, commonly known as a stomach pump, is the insertion of a tube into the stomach, followed by administration of water or saline down the tube. The liquid is then removed along with the contents of the stomach. Lavage has been used for many years as a common treatment for poisoned patients. However, a recent review of the procedure in poisonings suggests no benefit. It is still sometimes used if it can be performed within 1 hour of ingestion and the exposure is potentially life-threatening. ** Nasogastric aspiration involves the placement of a tube via the nose down into the stomach, the stomach contents are then removed by suction. This procedure is mainly used for liquid ingestions where activated charcoal is ineffective, e.g. ethylene glycol poisoning. ** Whole bowel irrigation cleanses the bowel. This is achieved by giving the patient large amounts of a polyethylene glycol solution. The osmotically balanced polyethylene glycol solution is not absorbed into the body, having the effect of flushing out the entire gastrointestinal tract. Its major uses are to treat ingestion of sustained release drugs, toxins not absorbed by activated charcoal (e.g., lithium, iron), and for removal of ingested drug packets (body packing/smuggling).


Enhanced excretion

* In some situations elimination of the poison can be enhanced using Forced diuresis, diuresis, hemodialysis, hemoperfusion, hyperbaric medicine, peritoneal dialysis, exchange transfusion or chelation. However, this may actually worsen the poisoning in some cases, so it should always be verified based on what substances are involved.


Epidemiology

In 2010, poisoning resulted in about 180,000 deaths down from 200,000 in 1990. There were approximately 727,500 emergency department visits in the United States involving poisonings—3.3% of all injury-related encounters.


Applications

Poisonous compounds may be useful either for their toxicity, or, more often, because of another chemical property, such as specific chemical reactivity. Poisons are widely used in industry and agriculture, as chemical reagents, solvents or complexing reagents, e.g. carbon monoxide, methanol and sodium cyanide, respectively. They are less common in household use, with occasional exceptions such as ammonia and methanol. For instance, phosgene is a highly reactive nucleophile acceptor, which makes it an excellent reagent for polymerizing diols and diamines to produce polycarbonate and polyurethane plastics. For this use, millions of tons are produced annually. However, the same reactivity makes it also highly reactive towards proteins in human tissue and thus highly toxic. In fact, phosgene has been used as a chemical weapon. It can be contrasted with sulfur mustard, mustard gas, which has only been produced for chemical weapons uses, as it has no particular industrial use. Biocides need not be poisonous to humans, because they can target metabolic pathways absent in humans, leaving only incidental toxicity. For instance, the herbicide 2,4-dichlorophenoxyacetic acid is a mimic of a plant growth hormone, which causes uncontrollable growth leading to the death of the plant. Humans and animals, lacking this hormone and its receptor, are unaffected by this, and need to ingest relatively large doses before any toxicity appears. Human toxicity is, however, hard to avoid with pesticides targeting mammals, such as rodenticides. The risk from toxicity is also distinct from toxicity itself. For instance, the preservative thiomersal used in vaccines is toxic, but the quantity administered in a single shot is negligible. File:Poisonings world map-Deaths per million persons-WHO2012.svg, upright=1.3, Deaths from poisonings per million persons in 2012 Image:Poisonings world map - DALY - WHO2004.svg, Disability-adjusted life year for poisonings per 100,000 inhabitants in 2004.


History

Throughout human history, intentional application of poison has been used as a method of murder, pest-control, suicide, and execution. As a method of execution, poison has been ingested, as the ancient Athenians did (see Socrates), inhaled, as with carbon monoxide or hydrogen cyanide (see gas chamber), injected (see lethal injection), or even as an enema. Poison's lethal effect can be combined with its allegedly magic (paranormal), magical powers; an example is the China, Chinese gu (poison), ''gu'' poison. Poison was also employed in gunpowder warfare. For example, the 14th-century Chinese text of the ''Huolongjing'' written by Jiao Yu outlined the use of a poisonous gunpowder mixture to fill cast iron grenade bombs.Needham, Joseph (1986). ''Science and Civilization in China: Volume 5, Part 7''. Taipei: Caves Books, Ltd. Page 180. While arsenic poisoning, arsenic is a naturally occurring environmental poison, its artificial concentrate was once nicknamed slayer rule, inheritance powder. In Middle Ages, Medieval Europe, it was common for monarchs to employ personal food tasters to thwart royal assassination, in the dawning age of the Apothecary.


Figurative use

The term poison is also used in a figurative sense. The slang sense of alcoholic drink is first attested 1805, American English (e.g., a bartender might ask a customer "what's your poison?" or "Pick your poison"). Figurative use of the term dates from the late 15th century. Figuratively referring to persons as poison dates from 1910. The figurative term poison pen letter became well known in 1913 by a notorious criminal case in Pennsylvania, U.S.; the phrase dates to 1898.


See also

* * * * * * * * * * * * * * *


References


External links


National Capital Poison Center

webPOISONCONTROL(R)

Agency for Toxic Substances and Disease Registry

American Association of Poison Control Centers

American College of Medical Toxicology

Clinical Toxicology Teaching Wiki

Find Your Local Poison Control Centre Here (Worldwide)

Poison Prevention and Education Website

Cochrane Injuries Group
, Systematic reviews on the prevention, treatment and rehabilitation of traumatic injury (including poisoning)
Pick Your Poison—12 Toxic Tales
by Cathy Newman {{Authority control Execution equipment Execution methods Suicide by poison Poisons