PncA is a gene encoding

pyrazinamidase PncA is a gene encoding pyrazinamidase in ''Mycobacterium'' species. Pyrazinamidase converts the drug pyrazinamide to the active form pyrazinoic acid. There is a strong correlation between mutations in pncA and resistance of ''M. tuberculosis'' ...

in ''

Mycobacterium ''Mycobacterium'' is a genus of over 190 species in the phylum Actinomycetota, assigned its own family, Mycobacteriaceae. This genus includes pathogens known to cause serious diseases in mammals, including tuberculosis (''Mycobacterium tuberculo ...

'' species.

Pyrazinamidase PncA is a gene encoding pyrazinamidase in ''Mycobacterium'' species. Pyrazinamidase converts the drug pyrazinamide to the active form pyrazinoic acid. There is a strong correlation between mutations in pncA and resistance of ''M. tuberculosis'' ...

converts the drug

pyrazinamide Pyrazinamide is a medication used to treat tuberculosis. For active tuberculosis, it is often used with rifampicin, isoniazid, and either streptomycin or ethambutol. It is not generally recommended for the treatment of latent tuberculosis. It i ...

to the active form

pyrazinoic acid Pyrazinoic acid is a pyrazinamide metabolite. Possible role in tuberculosis treatment Pyrazinamid is currently used as a treatment for tuberculosis. Mycobacterium tuberculosis converts pyrazinamid into pyrazinoic acid. The use of pyrazinoic acid ...

. There is a strong correlation between mutations in pncA and resistance of ''

M. tuberculosis ''Mycobacterium tuberculosis'' (M. tb), also known as Koch's bacillus, is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of tuberculosis. First discovered in 1882 by Robert Koch, ''M. tuberculosis'' ha ...

'' to pyrazinamide.

References

Enzymes Prokaryote genes Tuberculosis {{enzyme-stub

See also

References