embryology Embryology (from Ancient Greek, Greek ἔμβρυον, ''embryon'', "the unborn, embryo"; and -λογία, ''-logy, -logia'') is the branch of animal biology that studies the Prenatal development (biology), prenatal development of gametes (sex ...

, a neurogenic placode is an area of thickening of the

epithelium Epithelium or epithelial tissue is a thin, continuous, protective layer of cells with little extracellular matrix. An example is the epidermis, the outermost layer of the skin. Epithelial ( mesothelial) tissues line the outer surfaces of man ...

in the

embryo An embryo ( ) is the initial stage of development for a multicellular organism. In organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization of the female egg cell by the male sp ...

nic head

ectoderm The ectoderm is one of the three primary germ layers formed in early embryonic development. It is the outermost layer, and is superficial to the mesoderm (the middle layer) and endoderm (the innermost layer). It emerges and originates from the o ...

layer that gives rise to neurons and other structures of the

sensory nervous system The sensory nervous system is a part of the nervous system responsible for processing sense, sensory information. A sensory system consists of sensory neurons (including the sensory receptor cells), neural pathways, and parts of the brain invol ...

. Placodes are embryonic structures that give rise to structures such as hair follicles,

feathers Feathers are epidermis (zoology), epidermal growths that form a distinctive outer covering, or plumage, on both Bird, avian (bird) and some non-avian dinosaurs and other archosaurs. They are the most complex integumentary structures found in ...

and

teeth A tooth (: teeth) is a hard, calcified structure found in the jaws (or mouths) of many vertebrates and used to break down food. Some animals, particularly carnivores and omnivores, also use teeth to help with capturing or wounding prey, tear ...

. The term "neurogenic placode" generally refers to cranial placodes that have neurogenic potential - i.e. those that give rise to neurons associated with the

special senses In medicine and anatomy, the special senses are the senses that have specialized organs devoted to them: * vision (the eye) * hearing and balance (the ear, which includes the auditory system and vestibular system) * smell (the nose) * taste (th ...

and cranial ganglia. Cranial placodes include a diverse range of structures found across

chordates A chordate ( ) is a bilaterian animal belonging to the phylum Chordata ( ). All chordates possess, at some point during their larval or adult stages, five distinctive physical characteristics ( synapomorphies) that distinguish them from ot ...

, but the neurogenic placodes found in

vertebrates Vertebrates () are animals with a vertebral column (backbone or spine), and a cranium, or skull. The vertebral column surrounds and protects the spinal cord, while the cranium protects the brain. The vertebrates make up the subphylum Vertebra ...

arose later in evolution. The region in the ectoderm of the developing head that contains all the

precursor cell In cell biology, precursor cells—also called blast cells—are partially differentiated, or intermediate, and are sometimes referred to as progenitor cells. A precursor cell is a stem cell with the capacity to differentiate into only one cell ...

s for the cranial placodes is known as the preplacodal region.

In humans

The cranial placodes that have neurogenic potential (i.e. give rise to

neurons A neuron (American English), neurone (British English), or nerve cell, is an membrane potential#Cell excitability, excitable cell (biology), cell that fires electric signals called action potentials across a neural network (biology), neural net ...

) can be divided into two groups, the dorsolateral placodes and the epibranchial placodes. * dorsolateral placodes includes: ** The trigeminal placode, which consists of ophthalmic and maxillomandibular parts, and gives rise to the cells of the trigeminal ganglion ** The

otic placode In embryology, the otic placode is a thickening of the ectoderm on the outer surface of a developing embryo from which the ear develops. The ear, including both the vestibular system and the auditory system, develops from the otic placode beginni ...

forms the

otic pit The auditory pit, also known as the otic pit, is the first rudiment of the internal ear. It appears shortly after that of the eye, in the form of a patch of thickened ectoderm The ectoderm is one of the three primary germ layers formed in ear ...

and the

otic vesicle Otic vesicle, or auditory vesicle, consists of either of the two sac-like invaginations formed and subsequently closed off during embryonic development. It is part of the neural ectoderm, which will develop into the membranous labyrinth of the in ...

, giving rise eventually to organs of hearing and equilibrium. * The epibranchial or ''epipharyngeal'' placodes generate the distal portion of the ganglia of cranial nerves VII, IX and X: ** The geniculate placode, associated with the first

pharyngeal groove A pharyngeal groove (or branchial groove, or pharyngeal cleft) is made up of ectoderm unlike its counterpart the pharyngeal pouch on the endodermal side. The first pharyngeal groove produces the external auditory meatus The ear canal (external ...

, generates the

geniculate ganglion The geniculate ganglion (from Latin ''genu'', for "knee") is a bilaterally paired special sense ganglion of the intermediate nerve component of the facial nerve (CN VII). It is situated within facial canal of the head. It contains cell bodies ...

and distal parts of cranial nerve VII ** The petrosal placode, associated with the second pharyngeal groove, generates the inferior ganglion of glossopharyngeal nerve and distal parts of cranial nerve IX ** The nodosal placode, associated with the third branchial cleft, generates the nodose ganglion and distal parts of cranial nerve X * The

olfactory placode In embryology, the nasal placode (or olfactory placode) gives rise to the olfactory epithelium of the nose. Two nasal placodes arise as thickened ectoderm from the frontonasal process. They give rise to the nose, the philtrum of the upper lip, ...

(or ''nasal placode)'' gives rise to the

olfactory epithelium The olfactory epithelium is a specialized epithelium, epithelial tissue inside the nasal cavity that is involved in olfaction, smell. In humans, it measures and lies on the roof of the nasal cavity about above and behind the nostrils. The olfact ...

of the

nose A nose is a sensory organ and respiratory structure in vertebrates. It consists of a nasal cavity inside the head, and an external nose on the face. The external nose houses the nostrils, or nares, a pair of tubes providing airflow through the ...

. * The cranial placodes that do not give rise to neurons are: ** The lens placode under the direction of the

optic vesicle The eyes begin to develop as a pair of diverticula (pouches) from the lateral aspects of the forebrain. These diverticula make their appearance before the closure of the anterior end of the neural tube; after the closure of the tube around the 4t ...

gives rise to the lens of the eye. ** The adenohypophyseal placode, which forms the anterior lobe of the pituitary gland.

Other animals

* The profundal placode, corresponding to the ophthalmic lobe of the trigeminal complex. In

Xenopus ''Xenopus'' () (Gk., ξενος, ''xenos'' = strange, πους, ''pous'' = foot, commonly known as the clawed frog) is a genus of highly aquatic frogs native to sub-Saharan Africa. Twenty species are currently described with ...

, this remains partly unfused. * In fish and larval amphibians, the lateral line placodes, which give rise to the lateral line system. * The hypobranchial placodes, a neurogenic placode found in some

amphibians Amphibians are ectothermic, anamniote, anamniotic, tetrapod, four-limbed vertebrate animals that constitute the class (biology), class Amphibia. In its broadest sense, it is a paraphyletic group encompassing all Tetrapod, tetrapods, but excl ...

of unknown function

Other ectodermal placodes

The term ''placode'' or ''ectodermal placode'' is sometimes used to refer specifically to cranial or neurogenic placodes, but is also used for areas of the

that give rise to structures such as

mammary glands A mammary gland is an exocrine gland that produces milk in humans and other mammals. Mammals get their name from the Latin word ''mamma'', "breast". The mammary glands are arranged in organs such as the breasts in primates (for example, human ...

feather Feathers are epidermal growths that form a distinctive outer covering, or plumage, on both avian (bird) and some non-avian dinosaurs and other archosaurs. They are the most complex integumentary structures found in vertebrates and an exa ...

s and

hair Hair is a protein filament that grows from follicles found in the dermis. Hair is one of the defining characteristics of mammals. The human body, apart from areas of glabrous skin, is covered in follicles which produce thick terminal and ...

References

{{reflist Embryology of nervous system