Pityriasis Alba
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Pityriasis alba is a skin condition, a type of
dermatitis Dermatitis is a term used for different types of skin inflammation, typically characterized by itchiness, redness and a rash. In cases of short duration, there may be small blisters, while in long-term cases the skin may become thickened ...
, commonly seen in children and young adults as dry, fine-scaled, pale patches on the face. It is self-limiting and usually only requires use of moisturizer creams. The condition is so named for the fine scaly appearance initially present ( pityriasis), and alba (Latin for white) refers to the pallor of the patches that develop. The patches are not totally depigmented.


Signs and symptoms

The dry scaling appearance is most noticeable during the winter as a result of dry air inside people's homes. During the summer, tanning of the surrounding normal skin makes the pale patches of pityriasis alba more prominent. Individual lesions develop through 3 stages and sometimes are itchy: # Raised and red – although the redness is often mild and not noticed by parents # Raised and pale # Smooth flat pale patches Lesions are round or oval raised or flat, of 0.5–2 cm in size although may be larger if they occur on the body (up to 4 cm), and usually number from 4 or 5 to over 20. The patches are dry with very fine scales. They most commonly occur on the face (cheeks), but in 20% appear also on the upper arms, neck, or shoulders. The diagnostic differential should consider tinea and vitiligo amongst other causative factors.


Cause

Any
dermatitis Dermatitis is a term used for different types of skin inflammation, typically characterized by itchiness, redness and a rash. In cases of short duration, there may be small blisters, while in long-term cases the skin may become thickened ...
may heal leaving pale skin, as may excessive use of
corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are invo ...
creams used to treat episodes of
eczema Dermatitis is a term used for different types of skin inflammation, typically characterized by itchiness, redness and a rash. In cases of short duration, there may be small blisters, while in long-term cases the skin may become thickened ...
. The hypopigmentation is due to both reduced activity of
melanocyte Melanocytes are melanin-producing neural-crest, neural crest-derived cell (biology), cells located in the bottom layer (the stratum basale) of the skin's epidermis (skin), epidermis, the middle layer of the eye (the uvea), the inner ear, vagina ...
s with fewer and smaller melanosomes.Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. . The cause of pityriasis alba is not known. Dry skin and atopic dermatitis may co-exist. The patches may become more apparent after sun exposure, when the normal surrounding skin is tanned. The role of ultraviolet radiation, bathing or not bathing, low serum copper and '' Malassezia yeasts'' is not clear.


Diagnosis

Diagnosis is mainly done by clinical examination. Shining a Wood's light over the skin may reveal further lesions not obviously visible otherwise.


Differential diagnosis

* Pityriasis versicolor and
leprosy Leprosy, also known as Hansen's disease (HD), is a Chronic condition, long-term infection by the bacteria ''Mycobacterium leprae'' or ''Mycobacterium lepromatosis''. Infection can lead to damage of the Peripheral nervous system, nerves, respir ...
.


Treatment

No treatment is required and the patches in time will settle. The redness, scale and itch if present may be managed with simple emollients and sometimes
hydrocortisone Hydrocortisone is the name for the hormone cortisol when supplied as a medication. It is a corticosteroid and works as an anti-inflammatory and by immune suppression. Uses include conditions such as adrenocortical insufficiency, adrenogenit ...
, a weak steroid, is also used. As the patches of pityriasis alba do not darken normally in sunlight, effective sun protection helps minimise the discrepancy in colouration against the surrounding normal skin. Cosmetic camouflage may be required.
Tacrolimus Tacrolimus, sold under the brand name Prograf among others, is an immunosuppressive drug. After Allotransplantation, allogenic organ transplant, the risk of organ Transplant rejection, rejection is moderate. To lower the risk of organ rejectio ...
has been reported as speeding resolution. In exceptionally severe cases PUVA therapy may be considered.


Prognosis

The patches of pityriasis alba may last from 1 month to about one year, but commonly on the face last a year. However it is possible that the white patches may last for more than 1 year on the face.


Epidemiology

It occurs in mainly children and adolescents of all races, particularly people with dark skin. The worldwide prevalence is 5% in children, with boys and girls affected equally. adults can also have this disease. Up to a third of US school children may at some stage have this condition. Single-point prevalence studies from India have shown variable rates from 8.4% to 31%. Other studies have shown prevalence rates in Brazil of 9.9%, Egypt 13.49%, Romania 5.1%, Turkey 12% where higher rates were seen in those with poor socioeconomic conditions, and just 1% in school children in Hong Kong. In 1963, one school health clinic reported features of pityriasis alba in two fifths of their children.


History

It was first described in 1923. Having been known under a variety of names, the term 'Pityriasis alba', coined in 1956, has stayed.


See also

*
Leprosy Leprosy, also known as Hansen's disease (HD), is a Chronic condition, long-term infection by the bacteria ''Mycobacterium leprae'' or ''Mycobacterium lepromatosis''. Infection can lead to damage of the Peripheral nervous system, nerves, respir ...
*
List of cutaneous conditions Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the Human body, body and composed of Human skin, skin, hair, Nail (anatomy), nails, and related muscle and glands. The major function o ...
*
Vitiligo Vitiligo (, ) is a chronic autoimmune disorder that causes patches of skin to lose pigment or color. The cause of vitiligo is unknown, but it may be related to immune system changes, genetic factors, stress, or sun exposure, and susceptibili ...
which, by comparison, causes total loss of skin colour or on the face and tends to occur around the mouth and eyes.


References


External links

{{Pigmentation disorders Disturbances of human pigmentation