Piroheptine (brand name Trimol) is an

anticholinergic Anticholinergics (anticholinergic agents) are substances that block the action of the acetylcholine (ACh) neurotransmitter at synapses in the central nervous system, central and peripheral nervous system. These agents inhibit the parasympatheti ...

and

antihistamine Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. Typically, people take antihistamines as an inexpensive, generic (not patented) drug that can be bought without a prescription and provides ...

used as an

antiparkinsonian In the management of Parkinson's disease, due to the chronic nature of Parkinson's disease (PD), a broad-based program is needed that includes patient and family education, support-group services, general wellness maintenance, exercise, and nutr ...

agent. Piroheptine was observed to prevent the reuptake of dopamine and is therefore a DRI. Piroheptine comes from a family of drugs that includes pridefine and etifelmine.

Synthesis

A mixture of 2.6g of 5-(3-bromopropylidene)-10,11-dihydro-5H-dibenzo ,dycloheptene
PC1712685
(1), 0.34g MeCN, 5.2g PhCl and 2.1g stannic chloride (SnCl4) was heated in a closed vessel for 4 hr. After work-up there was obtained 1.1g of 2-methyl-3-(10,11-dihydro-5H-dibenzo ,dcycloheptene-5-ylidene)-1-pyrroline 6378-14-6(2). Quaternization of the product with ethyl iodide affords the alkyl immonium ion
PC29938260
(3). Reduction of the Schiff base with sodium borohydride then affords the product, piroheptine (4).

References

Antihistamines Antiparkinsonian agents Dibenzocycloheptenes H1 receptor antagonists Muscarinic antagonists Pyrrolidines {{nervous-system-drug-stub