Pirarubicin (
INN) is an
anthracycline drug.
An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than
doxorubicin and exhibits activity against some doxorubicin-resistant cell lines.
References
Anthracyclines
Topoisomerase inhibitors
Tetrahydropyrans
Hydroxyarenes
Phenol ethers
DNA intercalaters
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