Pipecuronium (Arduan) is a bisquaternary
aminosteroid muscle relaxant
A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate symptoms such as muscle spasms, pain, and hyperreflexia. The term "muscle relaxant" is used to refer to two major therapeu ...
which blocks
nicotinic acetylcholine receptors
Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral ner ...
at the
neuromuscular junction
A neuromuscular junction (or myoneural junction) is a chemical synapse between a motor neuron and a muscle fiber.
It allows the motor neuron to transmit a signal to the muscle fiber, causing muscle contraction.
Muscles require innervation to ...
. It is also an antagonist of
M2 and
M3 muscarinic receptors and is the most
potent neuromuscular blocking agent of the aminosteroid class.
It is sold under the
trade names Arduan and Pycuron.
See also
*
Pancuronium bromide
References
Muscle relaxants
Quaternary ammonium compounds
Piperazines
Acetate esters
Bromides
Nicotinic antagonists
Androstanes
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