Piclozotan (SUN-N4057) is a
selective 5-HT1A receptor partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given Receptor (biochemistry), receptor, but have only partial Intrinsic activity, efficacy at the receptor relative to a full agonist. They may also be considered Ligand (bio ...
, which has
neuroprotective
Neuroprotection refers to the relative preservation of neuronal structure and/or function. In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal l ...
effects in animal studies. It has been through early clinical trials in humans for treatment of acute
stroke
Stroke is a medical condition in which poor cerebral circulation, blood flow to a part of the brain causes cell death. There are two main types of stroke: brain ischemia, ischemic, due to lack of blood flow, and intracranial hemorrhage, hemor ...
, but results have not yet been announced.
See also
*
Repinotan
*
Robalzotan
References
Carboxamides
Benzoxazepines
2-Pyridyl compounds
Lactams
Organochlorides
Tetrahydropyridines
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