Phosducin-like protein is a
protein that in humans is encoded by the ''PDCL''
gene.
Phosducin-like protein is a putative modulator of
heterotrimeric G proteins
Heterotrimeric G protein, also sometimes referred to as the ''"large" G proteins'' (as opposed to the subclass of smaller, monomeric small GTPases) are membrane-associated G proteins that form a heterotrimeric complex. The biggest non-structura ...
. The protein shares extensive
amino acid sequence homology with
phosducin
Phosducin, also known as PDC, is a human protein and gene. It belongs to the phosducin family of proteins.
This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may part ...
, a
phosphoprotein expressed in the
retina and
pineal gland
The pineal gland, conarium, or epiphysis cerebri, is a small endocrine gland in the brain of most vertebrates. The pineal gland produces melatonin, a serotonin-derived hormone which modulates sleep, sleep patterns in both circadian rhythm, circ ...
. Both phosducin-like protein and phosphoducin have been shown to regulate
G-protein signaling by binding to the beta-gamma subunits of G proteins.
References
Further reading
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