Peter Verveer Tishler (July 18, 1937 – January 18, 2021) was a researcher in human

genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinians, Augustinian ...

and

orphan diseases A rare disease is any disease that affects a small percentage of the population. In some parts of the world, the term orphan disease describes a rare disease whose rarity results in little or no funding or research for treatments, without financi ...

, educator, and clinician especially in the areas of genetic diseases, including

polycystic kidney disease Polycystic kidney disease (PKD or PCKD, also known as polycystic kidney syndrome) is a genetic disorder in which the renal tubules become structurally abnormal, resulting in the development and growth of multiple cysts within the kidney. These ...

chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) is a type of progressive lung disease characterized by chronic respiratory symptoms and airflow limitation. GOLD defines COPD as a heterogeneous lung condition characterized by chronic respiratory s ...

Fabry disease Fabry disease, also known as Anderson–Fabry disease, is a rare genetic disease that can affect many parts of the body, including the kidneys, heart, brain, and skin. Fabry disease is one of a group of conditions known as lysosomal storage dis ...

, and the

porphyria Porphyria ( or ) is a group of disorders in which substances called porphyrins build up in the body, adversely affecting the skin or nervous system. The types that affect the nervous system are also known as Porphyria#Acute porphyrias, acute p ...

Biography

Tishler was born on July 18, 1937, in

Boston, Massachusetts Boston is the capital and most populous city in the Commonwealth (U.S. state), Commonwealth of Massachusetts in the United States. The city serves as the cultural and Financial centre, financial center of New England, a region of the Northeas ...

Max Tishler Max Tishler (October 30, 1906 – March 18, 1989) was president of Merck Sharp and Dohme Research Laboratories where he led the research teams that synthesized ascorbic acid, riboflavin, cortisone, pyridoxine, pantothenic acid, nicotinamide, ...

and Elizabeth M. Verveer, and grew up in

New Jersey New Jersey is a U.S. state, state located in both the Mid-Atlantic States, Mid-Atlantic and Northeastern United States, Northeastern regions of the United States. Located at the geographic hub of the urban area, heavily urbanized Northeas ...

. He passed away January 18, 2021, in

Watertown, New York Watertown is a city in and the county seat of Jefferson County, New York, United States. It is approximately south of the Thousand Islands, along the Black River, about east of where it flows into Lake Ontario. The city is bordered by the t ...

. Tishler attended public schools and

Harvard College Harvard College is the undergraduate education, undergraduate college of Harvard University, a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Part of the Harvard Faculty of Arts and Scienc ...

where he majored in

biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...

. He wrote his senior thesis on

carboxypeptidase A carboxypeptidase ( EC number 3.4.16 - 3.4.18) is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. This is in contrast to an aminopeptidases, which cleave peptide b ...

, in the lab of Dr. C.J. Fu at the Jimmy Fund, graduating ''

cum laude Latin honors are a system of Latin phrases used in some colleges and universities to indicate the level of distinction with which an academic degree has been earned. The system is primarily used in the United States. It is also used in some Sout ...

'' in 1959. Tishler attended

Yale School of Medicine The Yale School of Medicine is the medical school of Yale University, a private research university in New Haven, Connecticut. It was founded in 1810 as the Medical Institution of Yale College and formally opened in 1813. It is the sixth-oldest m ...

and graduated in 1962. While at Yale, Tishler began working with the Thorndike Memorial Laboratory at

Boston City Hospital The Boston City Hospital (1864–1996), in Boston, Massachusetts, was a public hospital located in the South End. It was "intended for the use and comfort of poor patients, to whom medical care will be provided at the expense of the city, and ...

from 1963 to 1977. William B. Castle, discoverer of

intrinsic factor Intrinsic factor (IF), also known as cobalamin binding intrinsic factor, or gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells (in humans) or chief cells (in rodents) of the stomach. It is necessary for the absorp ...

, introduced him to Sidney H. Ingbar with whom Tishler began work on the metabolic actions of

thyroid hormone File:Thyroid_system.svg, upright=1.5, The thyroid system of the thyroid hormones triiodothyronine, T3 and T4 rect 376 268 820 433 Thyroid-stimulating hormone rect 411 200 849 266 Thyrotropin-releasing hormone rect 297 168 502 200 Hypothalamus r ...

Maxwell Finland Maxwell Finland (March 15, 1902 – October 25, 1987) was an American scientist, medical researcher, and an expert on infectious diseases.] Finland led seminal research of antibiotic treatment of pneumonia. Early life and education Finland was ...

contributed to Tishler's scientific and clinical work.Finland, Maxwell and Castle, William B., Eds. (1983) ''The Harvard Medical Unit at Boston City Hospital, Volume II''. University of Virginia Press (for the Francis A. Countway Library of Medicine). Tishler's interest in genetics arose from his laboratory research in the study of thyroid function in patients with

phenylketonuria Phenylketonuria (PKU) is an inborn error of metabolism that results in decreased metabolism of the amino acid phenylalanine. Untreated PKU can lead to intellectual disability, seizures, behavioral problems, and mental disorders. It may also r ...

. During the

Vietnam War The Vietnam War (1 November 1955 – 30 April 1975) was an armed conflict in Vietnam, Laos, and Cambodia fought between North Vietnam (Democratic Republic of Vietnam) and South Vietnam (Republic of Vietnam) and their allies. North Vietnam w ...

, Tishler worked as a

Public Health Service The United States Public Health Service (USPHS or PHS) is a collection of agencies of the Department of Health and Human Services which manages public health, containing nine out of the department's twelve operating divisions. The Assistant Se ...

officer at the

National Institutes of Health The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...

. In the following years, he continued his basic laboratory work, but also was concerned with genetics and medicine in the terms of population and

epidemiology Epidemiology is the study and analysis of the distribution (who, when, and where), patterns and Risk factor (epidemiology), determinants of health and disease conditions in a defined population, and application of this knowledge to prevent dise ...

. He was also involved in familial studies of

hypertension Hypertension, also known as high blood pressure, is a Chronic condition, long-term Disease, medical condition in which the blood pressure in the artery, arteries is persistently elevated. High blood pressure usually does not cause symptoms i ...

at one of the first community health centers in the U.S., East Boston Neighborhood Health Center.

Selected publications

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References

External links

Peter Verveer Tishler
at

Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...

Peter Verveer Tishler
at the American Porphyria Foundation {{DEFAULTSORT:Tishler, Peter 1937 births 2021 deaths American epidemiologists American geneticists Medical educators Harvard University alumni American medical historians 21st-century American historians 21st-century American male writers American male non-fiction writers Writers from Boston