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Peroxynitrite (sometimes called peroxonitrite) is an ion with the formula ONOO. It is a structural isomer of
nitrate Nitrate is a polyatomic ion with the chemical formula . salt (chemistry), Salts containing this ion are called nitrates. Nitrates are common components of fertilizers and explosives. Almost all inorganic nitrates are solubility, soluble in wa ...
,


Preparation

Peroxynitrite can be prepared by the reaction of
superoxide In chemistry, a superoxide is a compound that contains the superoxide ion, which has the chemical formula . The systematic name of the anion is dioxide(1−). The reactive oxygen ion superoxide is particularly important as the product of t ...
with nitric oxide: : It is prepared by the reaction of
hydrogen peroxide Hydrogen peroxide is a chemical compound with the formula . In its pure form, it is a very pale blue liquid that is slightly more viscosity, viscous than Properties of water, water. It is used as an oxidizer, bleaching agent, and antiseptic, usua ...
with nitrite: : H2O2 + → ONOO + H2O Its presence is indicated by the absorbance at 302  nm (pH 12, ''ε''302 = 1670 M−1 cm−1).


Reactions

Peroxynitrite is weakly basic with a p''K''a of ~6.8. It is reactive toward DNA and
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
s. ONOO reacts nucleophilically with
carbon dioxide Carbon dioxide is a chemical compound with the chemical formula . It is made up of molecules that each have one carbon atom covalent bond, covalently double bonded to two oxygen atoms. It is found in a gas state at room temperature and at norma ...
. ''In vivo'', the concentration of carbon dioxide is about 1 mM, and its reaction with ONOO occurs quickly. Thus, under physiological conditions, the reaction of ONOO with carbon dioxide to form nitrosoperoxycarbonate () is by far the predominant pathway for ONOO. homolyzes to form carbonate radical and nitrogen dioxide, again as a pair of caged radicals. Approximately 66% of the time, these two radicals recombine to form carbon dioxide and nitrate. The other 33% of the time, these two radicals escape the solvent cage and become free radicals. It is these radicals ( carbonate radical and nitrogen dioxide) that are believed to cause peroxynitrite-related cellular damage.


Peroxynitrous acid

Its conjugate acid peroxynitrous acid is highly reactive, although peroxynitrite is stable in basic solutions.


See also

* Nitrotyrosine * Reactive nitrogen species


References

{{Nitrogen compounds Nitrogen oxyanions Atmospheric chemistry Toxins