The PeroxiBase database has been created at the

University of Geneva The University of Geneva (French: ''Université de Genève'') is a public university, public research university located in Geneva, Switzerland. It was founded in 1559 by French theologian John Calvin as a Theology, theological seminary. It rema ...

(

Switzerland Switzerland, officially the Swiss Confederation, is a landlocked country located in west-central Europe. It is bordered by Italy to the south, France to the west, Germany to the north, and Austria and Liechtenstein to the east. Switzerland ...

) at the end of 2003, by two plant biologists specialised in the study of plant

peroxidase Peroxidases or peroxide reductases ( EC numberbr>1.11.1.x are a large group of enzymes which play a role in various biological processes. They are named after the fact that they commonly break up peroxides, and should not be confused with other ...

s. It was first limited to class III peroxidases (plant peroxidases) and was then expanded to include all possible haem and non-haem peroxidase protein sequences. Many researchers and bioinformaticians from the University of Geneva joined their efforts to develop the database and rapidly increase the number of peroxidase sequences. Since 2005, the database accepts external contributions, which are verified by PeroxiBase curators. The majority of haem and non-haem

sequences can now be found in the PeroxiBase. The database is hosted by the

Swiss Institute of Bioinformatics The SIB Swiss Institute of Bioinformatics is an academic not-for-profit foundation which federates bioinformatics activities throughout Switzerland. The institute was established on 30 March 1998 and its mission is to provide core bioinform ...

. Peroxidase sequences come from other general public databases (

NCBI The National Center for Biotechnology Information (NCBI) is part of the National Library of Medicine (NLM), a branch of the National Institutes of Health (NIH). It is approved and funded by the government of the United States. The NCBI is loca ...

TIGR TIGR (an acronym of the place-names ''Trieste, Trst'', ''Istria, Istra'', ''Gorizia, Gorica'', and ''Rijeka, Reka''), fully the Revolutionary Organization of the Julian March T.I.G.R. (), was a Militant (word), militant Anti-fascism, anti-fascis ...

, UniProt KnowledgeBase: all the databases used are listed in the PeroxiBase), either as pre-existing annotated sequences, or from raw data (whole genomic sequencing projects).

Goals of the PeroxiBase

* To publicly (non-profit) provide the scientific community with a centralised platform regrouping information on peroxidase sequences. Possible applications: faster sequence search, phylogenetic analysis, expression profile determination * To manually re-annotate existing sequences (automated annotation sometimes leads to wrong predictions) * To acquire new sequences that are not yet available in other databases: non-annotated genomes, external contributions from sequencing groups

References

External links

Database homepage
{{Peroxidases Biological databases University of Geneva